About SARS-CoV-2 (2019nCoV, novel Coronavirus) Envelop protein (Coronavirus E protein) 1. SARS-CoV-2 (2019nCoV) E protein: E protein is the smallest major structural proteins. It has a N-terminal ectodomain and a C-terminal endodomain with ion channel activity. During the replication cycle, E protein is abundantly expressed inside the infected cell, but only a small portion is incorporated into […]
About SARS-CoV-2 (2019nCoV, novel Coronavirus) Spike protein, S1 Protein, Spike S1-NTD, Spike S1-CTD, Spike-RBD and Spike trimer protein. 1. SARS-CoV-2 (2019nCoV) Spike protein: SARS-CoV-2, a newly emerged pathogen spreading worldwide. The transmembrane spike (S) glycoprotein of SARS-CoV-2 that forms homotrimers protruding from the viral surface is known to mediate coronavirus entry into host cells. It has been […]
Figure. Validation of SARS-CoV-2 (2019nCoV) codon optimized (CO) Spike expression in HEK293 cell line by GeneMedi’s adenoviral vector (GMV-V-2019nCoV-053, GMV-V-2019nCoV-047) and lentiviral vector (GMV-V-2019nCoV-051) with Immunofluorescence (left) and Western Blot (right) by FLAG antibody. Collection of COVID-19 landscape knowledge base Viral vector-based vaccine; DNA-based vaccine; RNA based vaccine – A landscape for vaccine technology against infectious disease, COVID-19 and tumor. COVID-19 landscape […]
About Pre-made gene ORF plasmids for 2019 nCoV (SARS2 coronavirus, COVID-19) COVID-19, a novel pathogenic coronavirus (2019-nCoV or SARS-CoV2) induced disease, emerged in China and spread globally rapidly. GeneMedi offers pre-made gene ORF plasmids for 2019 nCoV (SARS2 coronavirus, COVID-19) as shown below: N protein(Nucleocapsid), S protein(Spike, full lenth), S1 protein(Spike), S protein RBDS protein […]
PSV validated Data Poster Download Protocol Download COVID-19 News and announcements collection on the new mutant variants of the SARS-CoV-2 (2019nCoV) virus – PHE investigating a novel variant of COVID-19– Rapid evaluation confirms lateral flow devices effective in detecting new COVID-19 variant– Confirmed cases of COVID-19 variant from South Africa identified in UK– Statement from […]
PSV validated Data Poster Download Protocol Download COVID-19 News and announcements collection on the new mutant variants of the SARS-CoV-2 (2019nCoV) virus – COVID-19 (SARS-CoV-2): information about the new virus variant – New SARS-COV-2 variant: information and risk assessment – Central Alerting System (CAS) alert – New variant clustering in households analysis (ONS) – SARS-CoV-2 […]
About COVID-19 pandemic, Coronavirus (Coronavirus) and genome of SARS-CoV-2 (2019nCoV) COVID-19 pandemic is caused by 2019nCoV (SARS-CoV-2, a novel coronavirus) infection.The 2019-nCoV genome was annotated to possess 14 ORFs encoding 27 proteins1. Figure. Schematic representative of genome structure and encoded gene of SARS-CoV-2 (2019nCoV)1 Table.Genome Annotation of 2019-nCoV1 Protein length(aa) orf1a 266-13483 4405 […]
About SARS-CoV-2 (2019nCoV, novel Coronavirus)Non-structure protein (Nsp1-Nsp16) 2019nCoV contains 16 Non-structure protein (Nsp1-Nsp16) that may be drugable targets for antiviral compounds discovery against COVID-191. Non-structure protein(NSP)information of SARS-CoV-2 (2019nCoV)1 nsp1 1 180 180 (leader protein) nsp2 181 818 638 nsp3 819 2763 1945 (Papain-Like proteinase, PLpro) nsp4 2764 3263 500 nsp5 […]
Table of Contents BACKGROUND Challenge of COVID-19 vaccine discovery & development: to meet accumulated mutating of SARS-CoV-2 and a long-term viral genome transcrption COVID-19 (Coronavirus Disease 2019) is novel viral pneumonia caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, also called 2019nCoV). The world is in midst of the COVID-19 pandemic. Effective vaccines are […]
Content index COVID-19, Why GeneMedi’s Multi-VariantsTM SARS-CoV-2 Pseudovirus Based Neutralization Assay system? The outbreak of COVID-19, caused by SARS-CoV-2 (2019-nCoV), has been a global pandemic and cause millions of people dead. The coronavirus is kept accumulated mutating. The most important mutation occurs in SARS-CoV-2 (2019nCoV) Spike protein (SARS-CoV-2 S protein). The SARS-CoV-2 (2019nCoV) Spike mediates […]
