This briefing provides an update on previous briefings up to 1 April 2021 Summary • There are 4 variants of concern and 7 variants under investigation (Table 1). VOC-20DEC-01 (B.1.1.7) remains predominant in the UK. Other variants of concern and variants under investigation remain a very low proportion of the available sequence data. VUI-21APR-01 (B.1.617.1) […]
Category Archives: diagnostic article
This briefing provides an update on previous briefings up to 11 March 2021 Summary • There are 4 variants of concern and 6 variants under investigation (Table 1). Definitions for variants of concern, variants under investigation and signals in monitoring have been updated. VOC-20DEC-01 (B.1.1.7) remains predominant. Other variants of concern and variants under investigation […]
Bone metabolism & osteoporosis Products List Download Table of Contents Case Study: GeneMedi’s GMP-h-β-CTx-Ab pairs (Anti-human β-CTx mouse monoclonal antibody) are validated to detect the GMP-h-β-CTx-Ag01 (Recombinant human β-CTx Protein) in ELISA Evidence has shown activated osteoclasts create resorption pits with low pH to dissolve the inorganic matrix and lysomal enzymes, such as TRAP and […]
Nanobodies are frequently compared to polyclonal, monoclonal antibodies, antibody fragments, and small molecules. The production of nanobodies is simple and cost effective compared to the polyclonal antibodies. Besides, Nbs are stable in a wide range of temperatures and pH levels. Nanobodies are also compatible with genetic engineering methods, which allow scaffolding and alteration of amino […]
Monoclonal antibodies (mAbs) against bacterial infections are more effective way to treat the antibiotic resistant strains. The antibacterial mAbs have several advantages such as reducing the antibiotic toxicity, treatment time and disease complications. there are numerous mAb products are under development for a range of infectious diseases. Currently, GeneMedi offers mAbs against gram negative bacteria, […]
Nanobodies have been used for both diagnostic and therapeutic application due to its high stability, refoldability, and manipulable characteristics. In addition, VHH has been effectively used as a research tool. In Vitro Diagnostic Tests Nbs have been recommended for both in vitro as well as in vivo diagnostic tests. Early diagnosis of both infection and […]
Clostridium difficile continues to be one of the most prevalent hospital-acquired bacterial infections in the developed world. Alternative approaches under investigation to combat the anaerobic Gram-positive bacteria include fecal transplantation therapy, vaccines, and antibody-based immunotherapies. Inhibitory antibodies that recognize the primary C. difficilevirulence factors, toxin A and toxin B, are the most popular passive immunotherapies under investigation. […]
Shiga toxins (Stxs) are cytotoxic proteins secreted by Shigella dysenteriae 1 and some serogroups of Escherichia coli (called Stx1 in E. coli). Shiga toxin producing E. coli (STEC) are foodborne pathogens that may colonize and damage the human colon to access to the bloodstream and damage the organs such as kidney and brain. Presently, there […]
The globalization of the world’s economies, accompanied by increasing international travel, changing climates, altered human behaviour and demographics is leading to the emergence of different viral diseases, many of which are highly pathogenic and hence are considered of great public and animal health importance. To undertake basic research and therapeutic development, many of these viruses […]
