Technical briefing 13 27 May 2021 This briefing provides an update on previous briefings up to 22 May 202 Summary There are 5 variants of concern and 9 variants under investigation (Table 1). This report has been published to continue to share detailed surveillance of VOC-21APR02 (B.1.617.2) and information on a new variant under investigation […]
Technical briefing 12 22 May 2021 This briefing provides an update on previous briefings up to 13 May 2021 Summary There are 5 variants of concern and 8 variants under investigation (Table 1). This report has been published to continue to share detailed surveillance of VOC-21APR02 (B.1.617.2) and information on a new variant under investigation […]
Technical briefing 11 13 May 2021 This briefing provides an update on previous briefings up to 7 May 2021 Summary There are 5 variants of concern and 7 variants under investigation (Table 1). This report has been published to continue to share detailed surveillance of VOC-21APR02 (B.1.617.2). A separate report is published covering our routine […]
Technical briefing 10 7 May 2021 This briefing provides an update on previous briefings up to 1 April 2021 Summary •There are 5 variants of concern and 8 variants under investigation (Table 1). VUI-21APR-02 (B.1.617.2) was escalated to a variant of concern on 6 May 2021 (VOC21APR-02). It is assessed as having at least equivalent […]
The basic engineering procedure for a VLP construction consists of three main steps: (A) cloning and expression of VLP in the expression system, (B) purification of VLP, and (C) formulation. The first step in VLP production is to clone the viral structural genes of interest and expressed in different expression systems including, prokaryotic (bacteria, yeast) […]
Virus-like particles (VLPs) are highly structured protein complexes that resemble a native virus capsid ranging 20–800 nm. It is made up of one or more different molecules with the ability to self-assemble and mimicking the form and size of a virus devoid of viral genome and are therefore non-infectious. VLPs in general can be either enveloped […]
Formats of bispecific antibodies (BsAbs) Many formats have been developed for BsAb generation as listed in the following table. Pipeline and MOA (mechanism of action) of bispecific antibodies (BsAbs) Bridge of 2 cells (engagers) By binding with 2 antigens from 2 different cells, the BsAbs can physically link them together, thus these kinds of BsAbs […]
Introduction about bispecific antibodies (BsAbs) Bispecific antibodies (BsAbs) are designed to bind two different epitopes or antigens, which leads to multiple mechanistic functions with synergistic effects. The attractive feature is their potential for novel functionalities, which do not exist in mixtures of the parental or reference antibodies. Till now, more than 200 BsAb-based clinical trails […]
Table of Contents FDA approved neutralizing antibodies (NAb) and our products 1. SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of protection to develop vaccines and immunotherapeutic against the virus. The RBD of spike […]
Pairwise Align Codons accepts two coding sequences and determines the optimal global alignment. The scoring matrix used to calculate the alignment is described in?Schneider et al. (2005). Use Pairwise Align Codons to look for conserved coding sequence regions. Only the bases A,C,G,T and U are used in the alignment. Click to use the tools>>Pairwise Align […]
