human, Cynomolgus/ Rhesus macaque, rat, mouse Interleukin 23, alpha subunit p19 (IL23A) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Cat:GM-Tg-hg-T06841-Ag-1
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Description

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse Interleukin 23, alpha subunit p19 (IL23A) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. IL-23 is produced by dendritic cells and macrophages. Interleukin-23 is a heterodimeric cytokine composed of an IL-12p40 subunit that is shared with IL-12 and the IL-23p19 subunit. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12R β1 and IL-23R. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration into tumours. IL-23 mediates its effects on both innate and adaptive arms of the immune system that express the IL-23 receptor. Th17 cells represent the most prominent T cell subset that responds to IL-23, although IL-23 has been implicated in inhibiting the development of regulatory T cell development in the intestine. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of other proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. The expression of IL23A is decreased after AHR knockdown in THP-1 cells and primary mouse macrophages.

Target Information

Target Name

IL23

Full name

Interleukin 23, alpha subunit p19

Gene ID

https://www.ncbi.nlm.nih.gov/gene/?term=51561

Gene Name

IL23A

Gene Alias

IL-23, IL-23A, IL23P19, P19, SGRF

Protein Sub-location

Secreted Protein/Potential Cytokines
Genemeidi Omicron Variant Products
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Antigen Information

Cat No.

GM-Tg-hg-T06841-Ag-1,GM-Tg-rg-T06841-Ag-1,GM-Tg-mg-T06841-Ag-1,GM-Tg-cynog-T06841-Ag-1

Product Name

Interleukin 23, alpha subunit p19 (IL23A) protein

Species

human, Cynomolgus/ Rhesus macaque, rat, mouse

Isotypes

Recombinant protein

Expression platform

Mammalian cell

Bioactivity validation

Affintiy&bioactivity validated by ELISA, cell culture validated

Tag

His

Product Description

Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse Interleukin 23, alpha subunit p19 (IL23A) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.

Purity

Purity: ≥95% (SDS-PAGE)

Application

Formulation

Supplied as a 0.2 μM filtered solution of PBS, PH7.4.

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.

GM-Tg-hg-T06841-Ab-1, GM-Tg-hg-T06841-Ab-2, GM-Tg-rg-T06841-Ab-1, GM-Tg-rg-T06841-Ab-2, GM-Tg-mg-T06841-Ab-1, GM-Tg-mg-T06841-Ab-2, GM-Tg-cynog-T06841-Ab-1, GM-Tg-cynog-T06841-Ab-2

Product Name

Anti-IL23/IL23A monoclonal antibody

Format

mab

Category of antibody

FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody

Derivation (species)

Mouse

Species Reactivity

CH1+2+3 Isotype (Receptor identification)

IgG

Type of Light Chain (VD-LC)

N/A

Expression platform

Mammalian Expression

Bioactivity validation

Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Tag

Fc

Products description

Pre-made anti-IL23 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)

Purity

Purity: ≥95% (SDS-PAGE)

Application

Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Formulation

Lyophilized from sterile PBS, PH 7.4

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.

GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.

Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.