human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 6 (BMP6) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Cat:GM-Tg-hg-T10762-Ag-1
* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry
SKU GM-Tg-hg-T10762-Ag-1 Categories ,

Description

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 6 (BMP6) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene. The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells. The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics April; 41 :386-8. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals.

Target Information

Target Name

BMP6

Full name

bone morphogenetic protein 6

Gene ID

https://www.ncbi.nlm.nih.gov/gene/?term=654

Gene Name

BMP6

Gene Alias

VGR, VGR1

Protein Sub-location

Secreted Protein/Potential Cytokines
Genemeidi Omicron Variant Products
test
Previous slide
Next slide

Antigen Information

Cat No.

GM-Tg-hg-T10762-Ag-1,GM-Tg-rg-T10762-Ag-1,GM-Tg-mg-T10762-Ag-1,GM-Tg-cynog-T10762-Ag-1

Product Name

bone morphogenetic protein 6 (BMP6) protein

Species

human, Cynomolgus/ Rhesus macaque, rat, mouse

Isotypes

Recombinant protein

Expression platform

Mammalian cell

Bioactivity validation

Affintiy&bioactivity validated by ELISA, cell culture validated

Tag

His

Product Description

Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 6 (BMP6) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.

Purity

Purity: ≥95% (SDS-PAGE)

Application

Formulation

Supplied as a 0.2 μM filtered solution of PBS, PH7.4.

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.

GM-Tg-hg-T10762-Ab-1, GM-Tg-hg-T10762-Ab-2, GM-Tg-rg-T10762-Ab-1, GM-Tg-rg-T10762-Ab-2, GM-Tg-mg-T10762-Ab-1, GM-Tg-mg-T10762-Ab-2, GM-Tg-cynog-T10762-Ab-1, GM-Tg-cynog-T10762-Ab-2

Product Name

Anti-BMP6 monoclonal antibody

Format

mab

Category of antibody

FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody

Derivation (species)

Mouse

Species Reactivity

CH1+2+3 Isotype (Receptor identification)

IgG

Type of Light Chain (VD-LC)

N/A

Expression platform

Mammalian Expression

Bioactivity validation

Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Tag

Fc

Products description

Pre-made anti-BMP6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)

Purity

Purity: ≥95% (SDS-PAGE)

Application

Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Formulation

Lyophilized from sterile PBS, PH 7.4

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.

GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.

Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.