human, Cynomolgus/ Rhesus macaque, rat, mouse erbb2 interacting protein (ERBB2IP) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Cat:GM-Tg-hg-T14597-Ag-1
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Description

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse erbb2 interacting protein (ERBB2IP) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. Erbb2 interacting protein (ERBB2IP), also known as erbin, is a protein which in humans is encoded by the ERBB2IP gene. Discovered in 1997, erbin is a 200kDa protein containing a PDZ domain. This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.

Target Information

Target Name

HER2

Full name

erbb2 interacting protein

Gene ID

https://www.ncbi.nlm.nih.gov/gene/?term=2064

Gene Name

ERBB2

Gene Alias

CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1

Protein Sub-location

Transmembrane Protein
Genemeidi Omicron Variant Products
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Antigen Information

Cat No.

GM-Tg-hg-T14597-Ag-1,GM-Tg-rg-T14597-Ag-1,GM-Tg-mg-T14597-Ag-1,GM-Tg-cynog-T14597-Ag-1

Product Name

erbb2 interacting protein (ERBB2IP) protein

Species

human, Cynomolgus/ Rhesus macaque, rat, mouse

Isotypes

Recombinant protein

Expression platform

Mammalian cell

Bioactivity validation

Affintiy&bioactivity validated by ELISA, cell culture validated

Tag

His

Product Description

Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse erbb2 interacting protein (ERBB2IP) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.

Purity

Purity: ≥95% (SDS-PAGE)

Application

Formulation

Supplied as a 0.2 μM filtered solution of PBS, PH7.4.

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.

GM-Tg-hg-T14597-Ab-1, GM-Tg-hg-T14597-Ab-2, GM-Tg-rg-T14597-Ab-1, GM-Tg-rg-T14597-Ab-2, GM-Tg-mg-T14597-Ab-1, GM-Tg-mg-T14597-Ab-2, GM-Tg-cynog-T14597-Ab-1, GM-Tg-cynog-T14597-Ab-2

Product Name

Anti-HER2/ERBB2 monoclonal antibody

Format

mab

Category of antibody

FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody

Derivation (species)

Mouse

Species Reactivity

CH1+2+3 Isotype (Receptor identification)

IgG

Type of Light Chain (VD-LC)

N/A

Expression platform

Mammalian Expression

Bioactivity validation

Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).

Tag

Fc

Products description

Pre-made anti-HER2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)

Purity

Purity: ≥95% (SDS-PAGE)

Application

Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Formulation

Lyophilized from sterile PBS, PH 7.4

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.

GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.

Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.