human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 7 (BMP7) for cell curture,in vitro study, in vivo study,benchmark, drug discovery & MOA research and positive control for the diagnosis.

Cat:GM-Tg-hg-T50289-Ag-1
* GeneMedi provides NON-PROFIT PRICE to support Academic research. Please click inquiry for product quotation. → Inquiry
SKU GM-Tg-hg-T50289-Ag-1 Categories ,

Description

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 7 (BMP7) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene. The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder. BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes. It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types.

Target Information

Target Name

BMP7

Full name

bone morphogenetic protein 7

Gene ID

https://www.ncbi.nlm.nih.gov/gene/?term=655

Gene Name

BMP7

Gene Alias

OP-1

Protein Sub-location

Secreted Protein/Potential Cytokines
Genemeidi Omicron Variant Products
test
Previous slide
Next slide

Antigen Information

Cat No.

GM-Tg-hg-T50289-Ag-1,GM-Tg-rg-T50289-Ag-1,GM-Tg-mg-T50289-Ag-1,GM-Tg-cynog-T50289-Ag-1

Product Name

bone morphogenetic protein 7 (BMP7) protein

Species

human, Cynomolgus/ Rhesus macaque, rat, mouse

Isotypes

Recombinant protein

Expression platform

Mammalian cell

Bioactivity validation

Affintiy&bioactivity validated by ELISA, cell culture validated

Tag

His

Product Description

Recombinant human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 7 (BMP7) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.

Purity

Purity: ≥95% (SDS-PAGE)

Application

Formulation

Supplied as a 0.2 μM filtered solution of PBS, PH7.4.

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Antibody Information

Catalog No.

GM-Tg-hg-T50289-Ab-1, GM-Tg-hg-T50289-Ab-2, GM-Tg-rg-T50289-Ab-1, GM-Tg-rg-T50289-Ab-2, GM-Tg-mg-T50289-Ab-1, GM-Tg-mg-T50289-Ab-2, GM-Tg-cynog-T50289-Ab-1, GM-Tg-cynog-T50289-Ab-2

Product Name

Anti-BMP7 monoclonal antibody

Format

mab

Category of antibody

FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody

Derivation (species)

Mouse

Species Reactivity

CH1+2+3 Isotype (Receptor identification)

IgG

Type of Light Chain (VD-LC)

N/A

Expression platform

Mammalian Expression

Bioactivity validation

Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Tag

Fc

Products description

Pre-made anti-BMP7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)

Purity

Purity: ≥95% (SDS-PAGE)

Application

Biological drug discovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Formulation

Lyophilized from sterile PBS, PH 7.4

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.

GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.

Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.