Cat:GMP-h-A1M
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Product Details

Genemedi produces core diagnostic ingredients for test of Kidney function (renal damages) (Proteinuria, preeclampsia,) and related syndrome. GeneMedi offers paired diagnostics grade Alpha-1-microglobulin (A1M) antibodies (monoclonal antibody, mab) and antigens for Kidney function (renal damages) (Proteinuria, preeclampsia,) rapid test kit of Alpha-1-microglobulin (A1M) testing in standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT. All the antibodies and antigens for Kidney function (renal damages) (Proteinuria, preeclampsia, ) test are suitable for in functional ELISA, and other immunoassays in dignostics.The antibodies can act as a capture antibody and detection antibody. The antigens can be used as positive control.Urinary microproteins are becoming increasingly important in clinical diagnostics. They can contribute in the non-invasive early detection of renal abnormalities and the differentiation of various nephrological and urological pathologies. Alpha-1-microglobulin (A1M, α1-microglobulin, sometimes also called Protein HC) is a microglobulin, a small globular protein. It is found in all vertebrates, including humans, and is distributed in blood plasma and extravascular tissues of all organs. It is synthesized in most cells of the body, but mainly in the liver from a gene that codes for the alpha-1-microglobulin/bikunin precursor. A1M can be used as an indicator of proteinuria. The test can be regarded as positive when the ratio of A1M (in milligrams) and creatinine in millimoles in the urine is over 0.7 mg/mmol. A test for preeclampsia, where A1M serves as the diagnostic marker, has been proposed. It is based upon the fact that oxidative stress in the placenta tissue triggers the endogenous synthesis and plasma concentration of the protein.Alpha 1-microglobulin (A1M) is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.

Product Description

Cat No. of Pruducts

GMP-h-A1M-Ag01:Recombinant Human A1M Protein

Product Name

Recombinant Human A1M Protein

Target

Alpha-1-microglobulin

Alias of Target/Biomarker

A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC

Expression platform

E.coli

Isotypes

Recombinant Antigen

Bioactivity validation

Alpha-1-microglobulin (A1M) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in A1M level test of Kidney function (renal damages) (Proteinuria, preeclampsia,) and related syndrome evaluation

Tag

His

Products description

Recombinant Human A1M Protein was expressed in E.coli -based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.

Reconized/Reactive Species

Human

Purity

Purity: ≥95% (SDS-PAGE)

Application

Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.

Formulation

Supplied as a 0.2 μM filtered solution of PBS,PH7.4.

Storage

Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
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Cat No. of Pruducts

GMP-h-A1M-Ab01,GMP-h-A1M-Ab02:Anti-Human A1M mouse monoclonal antibody (mAb)

Product Name

Anti-Human A1M mouse monoclonal antibody (mAb)

Target

Alpha-1-microglobulin (A1M)

Alias of Target/Biomarker

A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC

Expression platform

Hybridoma

Isotypes

Mouse IgG

Bioactivity validation

Human Alpha-1-microglobulin (A1M) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Alpha-1-microglobulin (A1M) antibodies in A1M level test of Kidney function (renal damages) (Proteinuria, preeclampsia,) and related syndrome evaluation.

Tag

mFc

Products description

Anti-Human A1M mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by hybridoma technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other Alpha-1-microglobulin (A1M) antibodies.

Reconized/Reactive Species

Human

Purity

Purity: ≥95% (SDS-PAGE)

Application

ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT

Formulation

Supplied as a 0.2 μM filtered solution of PBS,PH7.4.

Storage

Store at? -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Diagnostic antibodies and antigens for cancer detection - TG, CA-125, SCC Ag, PIVKA-Ⅱ, ProGRP, Calcitonin, NSE, CA-724, HE4, CA15-3, FER, CYFRA21-1, HER2, HSP90α, S100B, CEA, AFP, sFlt-1, PSA, hEGF, TFF2, TFF3, CA199, CA50, TK1

Regardless of the advances in the cancer therapy, delayed symptoms and lack of successful diagnosis of cancer at early stage increased the death rate. Tumor-associated antigens (TAAs) and their antibodies have been identified as potential markers in cancer diagnosis and determination. TAAs and their antibodies-based detection of cancer have the advantages such as low-cost, and simple access, which attracted much attention for early cancer detection. For several reasons, tumor marker itself is typically insufficient to analyze disease conditions. Because, maximum number of markers have been produced by both normal and cancer cells. Several cancers such as anal, breast, ovaries, testicles, colon, endometrial, peritoneal, fallopian tube, gallbladder, gastric, liver, lung, neuroendocrine, pancreatic, prostate, renal, cervix, stomach and thyroid cancer, bronchopulmonary dysplasia, hepatitis, hematological malignancies, hemochromatosis, hypercalcemia, osteoporosis, Parget’s diseases and so on have been identified using specific marker. Detecting the quantity of marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.