Genemedi produces core diagnostic ingredients for test of Cardiovascular disease (?myocardial infarction?) and related syndrome. GeneMedi offers paired diagnostics grade Cardiac troponin I (cTnI) antibodies (monoclonal antibody, mab) and antigens for Cardiovascular disease (?myocardial infarction?) rapid test kit of Cardiac troponin I (cTnI) testing in standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT. All the antibodies and antigens for Cardiovascular disease (?myocardial infarction? ) test are suitable for in functional ELISA, and other immunoassays in dignostics.The antibodies can act as a capture antibody and detection antibody. The antigens can be used as positive control.Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with a molecular weight of 23.9 kDa. It consists of 209 amino acid residues. The theoretical pI of cTnI is 9.05.[3]?cTnI differs from other troponins due to its N-terminal extension of 26 amino acids. This extension contains two serines, residues 23 and 24, which are phosphorylated by?protein kinase A?in response to beta-adrenergic stimulation and important in increasing the inotropic response.[4]?Phosphorylation of cTnI changes the conformation of the protein and modifies its interaction with other troponins as well as the interaction with anti-TnI antibodies. These changes alter the myofilament response to calcium, and are of interest in targeting heart failure. Multiple reaction monitoring of cTnI has revealed that there are 14 phosphorylation sites and the pattern of phosphorylation observed these sites is changed in response to disease.[5]?cTnI has been shown to be phosphorylated by protein kinase A,?protein kinase C,?protein kinase G, and?p21-activated kinase 3.[6]?A significant part of cTnI released into the patient’s blood stream is phosphorylated.[7]?For more than 15 years cTnI has been known as a reliable marker of cardiac muscle tissue injury. It is considered to be more sensitive and significantly more specific in diagnosis of the myocardial infarction than the “golden?marker” of last decades –?CK-MB, as well as total?creatine kinase,?myoglobin?and?lactate dehydrogenase?isoenzymes.