Diagnostic anti-Clostridium perfringens Epsilon antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig, Avian/Bird/Poultry infectious disease Clostridial enterotoxicosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Genemedi produces core animal health diagnostic ingredients-validated anti-Clostridium perfringens Epsilon antibodies pairs and antigens for rapid test kit of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig, Avian/Bird/Poultry infectious disease with Clostridial enterotoxicosis to evaluate the  animal health of Multiple species (Avian/Bird/Poultry, Pet, Ruminants, Equine/Horse, Swine/Porcine/Pig). The paired antibodies are both monoclonal antibody (mab). All the antibodies and antiges of animal disease test are suitable for in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT. The antibody can act as a capture antibody and detection antibody. Antigens are validated as positive control materials. The gram positive anaerobic bacterium Clostridium perfringens belongs to the physiological intestinal flora of many mammals and is facultative pathogenic. Inconvenient endogeneous (other basic diseases, diarrhoea pathogens, antibiotic therapies with massive reduction of intestinal flora etc.) and exogeneous (farming conditions, extreme changes of the food, stress etc.) factors can lead to an increased pathogenicity of C. perfringens. Next to its ability to form extremely infectious and stable spores, the formation of lethal toxins is crucial for its pathogenicity. The classification into the various types (A–E) is only due to the toxin formation. These toxins can cause extremely variable (mild to lethal progression forms) failures of the intestinal water and electrolyte balance in the different species like goat, sheep (e. g. dysenteria of lambs: type B; pulpy kidney disease: type D), cattle (haemorrhagic enteritis: type A–E), foal (haemorrhagic necrotising enteritis: type A & C) and piglet (e. g. serous-catarrhal enteritis: type A, necrotising enteritis: type C). In the dog, especially serotype A occurs, producing 2 main toxins (toxin Alpha [α] and a Clostridia enterotoxin [CPE]), rarer serotype B (toxin Beta [β]). Both C. perfringens and its CPE can be detected also in healthy dog’s feces. The CPE can be detected more often in dogs with diarrhoea compared to healthy dogs. CPE is more frequent in dogs with diarrhoea (haemorrhagic gastroenteritis, acute or chronic diarrhoea, enterotoxaemia) than in healthy dogs. For cats, to date reliable literature data concerning prevalence and clinical relevance are missing. Only by detection of C. perfringens in the feces, a disease caused by Clostridia is not diagnosable. In a study in Switzerland, 54 % of the C. perfringens isolates showed a reduced sensitivity towards metronidazole or 18 % towards tetracycline. Because there is a general risk of resistance formation, it is recommended to identify the triggering pathogen in principle.