human TCL1A Lentivirus plasmid
Cat:pGMLP000066
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMLP000066
Gene Name
TCL1A
Product Name
human TCL1A Lentivirus plasmid
Accession Number
NM_021966
Gene ID
8115
Species
human
Product Type
Lentivirus plasmid
Insert Length
345
Gene Alias
TCL1
Fluorescent Label
GFP+PURO
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Maker
GFP+PURO
Regulation
overexpression
