Introduction about bispecific antibodies (BsAbs) Bispecific antibodies (BsAbs) are designed to bind two different epitopes or antigens, which leads to multiple mechanistic functions with synergistic effects. The attractive feature is their potential for novel functionalities, which do not exist in mixtures of the parental or reference antibodies. Till now, more than 200 BsAb-based clinical trails […]
Tag Archives: trafficpage2
The basic engineering procedure for a VLP construction consists of three main steps: (A) cloning and expression of VLP in the expression system, (B) purification of VLP, and (C) formulation. The first step in VLP production is to clone the viral structural genes of interest and expressed in different expression systems including, prokaryotic (bacteria, yeast) […]
Virus-like particles (VLPs) are highly structured protein complexes that resemble a native virus capsid ranging 20–800 nm. It is made up of one or more different molecules with the ability to self-assemble and mimicking the form and size of a virus devoid of viral genome and are therefore non-infectious. VLPs in general can be either enveloped […]
Bridge of 2 cells (engagers) By binding with 2 antigens from 2 different cells, the BsAbs can physically link them together, thus these kinds of BsAbs are named “engagers”. The redirecting of immune cells to tumor cells by the engagers makes the immune cell activated and then eliminate the target cells. The T cell engagers […]
Formats of bispecific antibodies (BsAbs) Many formats have been developed for BsAb generation as listed in the following table. Pipeline and MOA (mechanism of action) of bispecific antibodies (BsAbs) Bridge of 2 cells (engagers) By binding with 2 antigens from 2 different cells, the BsAbs can physically link them together, thus these kinds of BsAbs […]
Hepatitis B virus (HBV) neutralizing antibodies (NAb) Hepatitis B virus (HBV) surface antigen (HBsAg) is considered to be the most important target for the diagnosis and immune prophylaxis of HBV infection. HBsAg-specific monoclonal antibodies (MAbs) are extensively used for studying the complex structure of the HBsAg, mapping the neutralizing epitopes and development of HBV diagnostic […]
Human Immunodeficiency Virus (HIV) neutralizing antibodies (NAb) The glycoprotein (gp) 120 subunit is an important part of the envelope spikes that decorate the surface of HIV-1 and a major target for neutralizing antibodies. FDA approved neutralizing antibodies (NAb) and our products 1. SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 […]
SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of protection to develop vaccines and immunotherapeutic against the virus. The RBD of spike plays a critical role in the very first step of the virus […]
FDA approved neutralizing antibodies (NAb) and our products 1. SARS-CoV-2 neutralizing antibodies (NAb) SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of protection to develop vaccines and immunotherapeutic against the virus. The RBD of spike plays a critical […]
Definition–What is neutralizing antibody (NAb)? Regarding neutralizing antibody activity, Neutralization can be achieved through four main mechanisms2: (1)NAbs binding to viral surface proteins and blocking their interaction with the host cell receptor and infection; (2)NAbs binding to viral protein epitopes that interact with host cell coreceptors that are key for viral infection; (3)NAbs binding to viral […]
