Diagnostic recombinant myelin oligodendrocyte glycoprotein (MOG) antigens (recombinant myelin oligodendrocyte glycoprotein (MOG) ) protein) for inflammation/autoimmune/ inflammatory diseaseMOG detection in ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Product Details
Myelin oligodendrocyte glycoprotein antibody disorders (MOGAD) is an idiopathic, inflammatory, demyelinating disease of the central nervous system (CNS). MOG is a glycoprotein uniquely expressed in oligodendrocytes in the CNS. MOG antibodies were originally thought to be involved in multiple sclerosis (MS), but subsequent studies found it to be a distinct disease. MOGAD have many similarities to neuromyelitis optica but several studies have demonstrated they have unique clinical features, treatment response, and prognosis. MOGAD were initially identified in NMOSD antibody negative patients. Pathologically NMOSD is classified as am astrocytopathy, while MOGAD are classified as oligodendrogliopathies.
The MOG antibody can distinguish a spectrum of autoimmune demyelinating diseases from multiple sclerosis (MS). Testing positive for the MOG antibody indicates that a patient doesn’t have classical MS.
That’s important because diseases associated with the MOG antibody ?? as well as diseases associated with the water channel aquaporin-4 (AQP4) antibody, which was discovered at Mayo Clinic ?? are commonly misdiagnosed as MS. Yet some MS medications have been reported to worsen diseases that mimic MS.
Which patients would benefit from this antibody testing?
Any patient who suddenly presents with vision loss, significant disk edema or recurrent optic neuritis should consider testing for both MOG and AQP4 antibodies. Patients who have more than one episode of optic neuritis absolutely should have testing. An optic neuritis seems to be a very common presentation of MOG.Genemedi produces core diagnostic ingredients for test of inflammation/autoimmune/
inflammatory disease and related syndrome.
GeneMedi offers paired diagnostics grade myelin oligodendrocyte glycoprotein (MOG) antibodies (monoclonal antibody, mab) and myelin oligodendrocyte glycoprotein (MOG) antigens for inflammation/autoimmune/
inflammatory disease rapid test kit of myelin oligodendrocyte glycoprotein (MOG) testing in ELISA test,Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
All the antibodies and antigens for inflammation/autoimmune/
inflammatory disease test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibodies can act as a capture antibody and detection antibody. The antigens can be used for antibodies rapid test of inflammation/autoimmune/
inflammatory disease.
Product Description
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Antigen & Antibody Name
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Expression platform
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Isotypes
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Bioactivity validation
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Tag
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Products description
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Purity
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Application
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Formulation
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Storage
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Cat No.
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GMP-MOG-Ag
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Product Name
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Recombinant human Human MOG Protein
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Expression platform
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E.coli
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Isotypes
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Recombinant Antigen
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Bioactivity validation
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myelin oligodendrocyte glycoprotein (MOG) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in MOG level test of Inflammation/autoimmune/inflammatory disease (MOG antibody disease) and related syndrome evaluation
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Tag
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His
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Products description
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Recombinant human Human MOG Protein was expressed in E.coli -based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
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Purity
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Purity: ≥95% (SDS-PAGE)
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Application
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Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
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Formulation
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Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
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Storage
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Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.
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Diagnostic antibodies and antigens for infectious disease testing including HIV/AIDS, HCV, Influenza A/B, Syphilis, Helicobacter pylori, HSV-1/2, CMV, rubella virus, toxoplasma.
Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction.
Genemedi produces core diagnostic ingredients for test of infectious diseases and related syndrome.
GeneMedi offers paired diagnostics grade antibodies (monoclonal antibody,mab)and antigens for infectious disease rapid test kit including infection of HIV/AIDS,Hepatitis C virus(HCV), Influenza A/B,Treponema Pallidum caused Syphilis,Helicobacter pylori (H. pylori) Bacteria, Herpes simplex virus 1/2(HSV-1/HSV-2),Cytomegalovirus (CMV),rubella virus,toxoplasma gondii and so on.
All the antibodies of inflammation and CRS test are suitable for in functional ELISA, and other immunoassays in dignostics. The antibody can act as a capture antibody and detection antibody.
