rat Nfe2l2 AAV plasmid
Cat:pGMAAV000087
Availability:3-7 business days
Description
Catalog ID
pGMAAV000087
Gene Name
Nfe2l2
Product Name
rat Nfe2l2 AAV plasmid
Accession Number
NM_031789.2
Gene ID
83619
Species
rat
Product Type
AAV plasmid
Insert Length
1794
Gene Alias
Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule metabolic process; and regulation of cell migration. Located in cytoplasm and nucleus. Used to study several diseases, including diabetic retinopathy; liver cirrhosis; middle cerebral artery infarction; non-alcoholic fatty liver disease; and visual epilepsy. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); neurodegenerative disease (multiple); non-alcoholic steatohepatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer’s disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
NULL
Fusion Tag
flag
Promoter
CMV
Resistance
Amplicin
gene description
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
Maker
Regulation
overexpression
