Cat:pGMAD000286
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMAD000286
Gene Name
Bmp2
Product Name
Accession Number
NM_017178
Gene ID
29373
Species
rat
Product Type
Adenovirus plasmid
Insert Length
1182
Gene Alias
Enables growth factor activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including BMP signaling pathway; cellular response to mechanical stimulus; and response to retinoic acid. Acts upstream of or within positive regulation of neurogenesis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; extracellular space; and vesicle. Part of protein-containing complex. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
NULL
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Maker
NULL
Regulation
overexpression
