Cat:pGMAD000640
If you purchase ORF/cDNA clone-Lentivirus plasmid, ORF vector will be delivered with P-ALV-B11 backbone together.
Availability:3-7 business days
Description
Catalog ID
pGMAD000640
Gene Name
Cdc42
Product Name
Accession Number
NM_009861.3
Gene ID
12540
Species
house mouse
Product Type
Adenovirus plasmid
Insert Length
576
Gene Alias
Enables several functions, including GTP-dependent protein binding activity; GTPase activity; and Rho GDP-dissociation inhibitor binding activity. Involved in several processes, including dendritic spine morphogenesis; heart development; and positive regulation of cellular component organization. Acts upstream of or within several processes, including cellular response to interferon-gamma; filopodium assembly; and positive regulation of phosphatidylinositol 3-kinase activity. Located in several cellular components, including leading edge membrane; phagocytic vesicle; and storage vacuole. Is active in cell leading edge. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and immune system. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]
Fluorescent Label
GFP
Fusion Tag
3×flag
Promoter
CMV
Resistance
Amplicin
gene description
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Maker
GFP
Regulation
overexpression
