Cytokines and Growth Factors-GeneMedi Descrition: An Lanscape of Cytokines & Growth Factors, including family classification, functional and reagent products list

Cytokines are small cell-signaling proteins that are secreted by numerous cell types (some of the cytokines are transmembrane proteins). Importantly, most cytokines function in their local microenvironment, rather than in a systemic manner. Cytokines bind to specific cell surface receptors, thereby activating intracellular signaling cascades that involve phosphorylation events that ultimately result in gene transcription. They are crucial to innate and adaptive inflammatory responses, cell growth and differentiation, cell death, angiogenesis and developmental as well as repair processes. Because of their involvement in immune and inflammatory responses, cytokines hold promise as therapeutic targets.

GeneMedi (GM) has plentiful expertise and experience in cytokines & growth factors product development and manufacturing. GM provides various cytokines for applications such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis. The classification of the cytokines includes adipokine, TNF superfamily, VEGF family, chemokines and chemokine receptors, IL-1 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, activins family, SMAD family, BMP family, IGF family, FGF family, WNT family, GDF family, EGF family, interferons (IFNS) family, NOTCH family, PDGF family, TGF-BETA family, and GDNF family.

Most of GM’s cell-culture grade cytokines and growth factors products are validated and highly evaluated by global researchers both in academia and industry.

Classification

Adipokine TNF Superfamily VEGF Family Chemokines and Chemokine Receptors IL-1 Family IL-6 Family IL-10 Family IL-12 Family IL-17 Family Activins Family SMAD Family BMP Family IGF Family FGF Family Wnt Family GDF Family EGF Family Interferons (IFNs) Family Notch Family PDGF Family TGF-beta Family GDNF Family

Adipokine

Classification: Energy balance and metabolism Brown fat Inflammation Thrombosis and hypertension Growth factors

Energy balance and metabolism

The diversity of the adipokines is considerable, in terms of both protein structure and function. Adipokines in energy metabolism has revealed that adipose tissue is a very important metabolically active endocrine organ. White, brown, and beige adipose tissue generate and secrete adipokines, such as adiponectin, leptin and so on, which facilitate adipose tissue-liver crosstalk and insulin sensitivity. The adipokine secretion pattern reflects adipose tissue function and seems to be important for determining the individual risk to develop metabolic and cardiovascular disease. When adipose tissue inflammation and dysfunction have developed, adipokine secretion is significantly changed towards a diabetogenic, proinflammatory, and atherogenic pattern. Since, adipokines play important roles in the regulation of appetite and satiety, fat distribution, insulin sensitivity and insulin secretion, energy expenditure, inflammation, blood pressure, hemostasis, and endothelial function, they are promising candidate molecules for future treatment of obesity and obesity related diseases. GENEMEDI developed the cytokines related to the energy metabolism such as allergen 1, retinol binding protein 4, plasma, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 dipeptidylpeptidase 4, adiponectin, C1Q and collagen domain containing intelectin 1 (galactofuranose binding), nicotinamide phosphoribosyltransferase, apelin, retinoic acid receptor responder (tazarotene induced) 2, resistin, leptin, complement factor D (adipsin) and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
RBP4	Human, Cynomolgus/Rhesus macaque, rat, mouse	retinol binding protein 4, plasma (RBP4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-RBP4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SERPINA12	Human, Cynomolgus/Rhesus macaque, rat, mouse	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (SERPINA12) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SERPINA12 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
DPP4	Human, Cynomolgus/Rhesus macaque, rat, mouse	dipeptidylpeptidase 4 (DPP4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-DPP4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ITLN1	Human, Cynomolgus/Rhesus macaque, rat, mouse	intelectin 1 (galactofuranose binding) (ITLN1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ITLN1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NAMPT	Human, Cynomolgus/Rhesus macaque, rat, mouse	nicotinamide phosphoribosyltransferase (NAMPT) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NAMPT monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
APLN	Human, Cynomolgus/Rhesus macaque, rat, mouse	apelin (APLN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-APLN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
RARRES2	Human, Cynomolgus/Rhesus macaque, rat, mouse	retinoic acid receptor responder (tazarotene induced) 2 (RARRES2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-RARRES2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
RETN	Human, Cynomolgus/Rhesus macaque, rat, mouse	resistin (RETN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-RETN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
LEP	Human, Cynomolgus/Rhesus macaque, rat, mouse	leptin (LEP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-LEP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CFD	Human, Cynomolgus/Rhesus macaque, rat, mouse	complement factor D (adipsin) (CFD) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CFD monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Brown fat

Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Brown adipose tissue functions to regulate body temperature through non-shivering thermogenesis; the dissipation of chemical energy to produce heat. Brown and activated beige cells are characterized by high levels of fatty acid β-oxidation, mitochondrial content, and thermogenesis. Activated brown adipocytes alter systemic energy metabolism, increasing substrate oxidation and energy expenditure, with potential for therapeutic exploitation for metabolic diseases including Type 2 diabetes mellitus (T2DM) and obesity. GENEMEDI developed the brown fat such as fibroblast growth factor 21, insulin-like growth factor-I and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
FGF21	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 21 (FGF21) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF21 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGF1R	Human, Cynomolgus/Rhesus macaque, rat, mouse	Insulin-like Growth Factor-I (IGF1R) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGF1R monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Inflammation

The adipokines possess pro- and anti-inflammatory properties and play a critical role in integrating systemic metabolism with immune function. In calorie restriction and starvation, proinflammatory adipokines decline and anti-inflammatory adipokines increase, which informs the host of energy deficits and contributes to the suppression of immune function. In individuals with normal metabolic status, there is a balance of pro- and anti-inflammatory adipokines. This balance shifts to favor proinflammatory mediators as adipose tissue expands during the development of obesity. As a consequence, the proinflammatory status of adipose tissue contributes to a chronic low-grade state of inflammation and metabolic disorders associated with obesity. These disturbances are associated with an increased risk of metabolic disease, type 2 diabetes, cardiovascular disease, and many other pathological conditions. GENEMEDI developed the cytokines related to the adipokines dependent inflammations such as interleukin 10, interleukin 1 alpha, chemokine (C-C motif) ligand 2, interleukin 8, tumor necrosis factor, interleukin 6 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL10	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 10 (IL10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1A	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 1, alpha (IL1A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL2	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 2 (CCL2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL8	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 8 (IL8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNF	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor (TNF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL6	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 6 (IL6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Thrombosis and hypertension

Normal adipose tissue maintains a specifically balanced adipokine profile, which modulates vascular homeostasis via endocrine and paracrine pathways. Excessive accumulation of adipose tissue may alter the expression of the adipokine profile and consequently the physiological effects of adipokines on the vessels. Excessive weight gain contributes to increased blood pressure in most patients with essential hypertension. The involvement of adipose tissue to increase the thrombotic tendency has been proposed through several direct and indirect mechanisms involving endothelial dysfunction together with platelet function abnormalities, enhanced coagulation, and hypo-fribrinolysis. Direct effects include the synthesis and secretion of plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) by adipose tissue, whereas the indirect effects are mainly mediated through the release of adipokines/inflammatory mediators and the oxidative environment which enhance platelet activity, induce liver production of coagulation factors and changes the vessel wall overall contributing to the thrombotic propensity found in obesity. GENEMEDI developed the cytokines related to the thrombosis and hypertension such as angiotensin 1-7, serum amyloid A, C-reactive protein (pentraxin-related), serpin peptidase inhibitor (clade E (nexin, plasminogen activator inhibitor type 1), member 1) and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
CRP	Human, Cynomolgus/Rhesus macaque, rat, mouse	C-reactive protein, pentraxin-related (CRP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CRP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SERPINE1	Human, Cynomolgus/Rhesus macaque, rat, mouse	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SERPINE1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Growth factors

Growth factors are biologically active molecules secreted in the body, which can affect cell growth and promote mitosis. They can cause altered gene expression by affecting various signal transduction pathways. Several growth factors that are either protein (over 50 amino acid residues) or peptides (2–50 amino acid residues) exhibit high affinity for specific receptors on the cell surface. The target receptor cell surface are mainly plasma membrane-bound proteins that show tyrosine kinase activity. Furthermore, some hormones that affect the cell growth such as estrogen and progestogens are considered as growth factors. Recent literature has shown that growth factors are essential for various physiological function such as wound healing and cancer among others. some growth factors that are expressed in adipose tissues have their impact on adipogenesis and other disease conditions. GENEMEDI developed the cytokines related to the growth factor such as hepatocyte growth factor and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
HGF	Human, Cynomolgus/Rhesus macaque, rat, mouse	hepatocyte growth factor (HGF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-HGF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NGF	Human, Cynomolgus/Rhesus macaque, rat, mouse	Nerve growth factor (NGF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NGF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

TNF Superfamily

Tumor necrosis factor (TNF) super family composes of a group of cytokines and their receptors which can reduce cell death (apoptosis). TNF is important for immunity and inflammation, and is part of the host response to bacteria, viruses and cancers. Local increases of TNF around sites of injury induce cardinal signs of inflammation, which include heat, swelling, pain and redness. Initially used to treat cancers, in some systems TNF can promote tumor progression. While there are many problems associated with systemic high dose treatment with TNF, recent evidence has demonstrated that local administration in conjunction with interferon γ (IFNγ), promotes the regression of adenomas and melanomas in patients due to apoptosis of the angiogenic endothelium. This superfamily is composed of 19 ligands and 29 receptors in humans. TNFα and Lymphotoxin-alpha (LTα) is first identified members of the family. The TNF family of ligands and receptors has been targeted for use in combination with chemotherapeutic treatment in cancer therapy. GENEMEDI developed the tumor necrosis factor (ligand) superfamily member 13, tumor necrosis factor (ligand) superfamily member 18, tumor necrosis factor receptor superfamily member 22, tumor necrosis factor, alpha-induced protein 8-like 2 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: TNF Superfamily Ligands TNF Superfamily Regulators

TNF Superfamily Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
CD154	Human, Cynomolgus/Rhesus macaque, rat, mouse	CD40 ligand (CD154) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CD154 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CD70	Human, Cynomolgus/Rhesus macaque, rat, mouse	CD70 antigen (CD70) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CD70 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
EDA	Human, Cynomolgus/Rhesus macaque, rat, mouse	ectodysplasin A (EDA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EDA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FASL	Human, Cynomolgus/Rhesus macaque, rat, mouse	Fas ligand (TNF superfamily, member 6) (FASL) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FASL monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
LTB	Human, Cynomolgus/Rhesus macaque, rat, mouse	lymphotoxin beta (TNF superfamily, member 3) (LTB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-LTB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFAIP3	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFAIP3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFAIP6	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFAIP6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF10A	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF10A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF10B	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF10B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF10C	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF10C monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF11A	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF11A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF11B	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF11B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF12A	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF12A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF13B	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF13B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF13C	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF13C monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF14	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF14 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF17	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 17 (TNFRSF17) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF17 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF18	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 18 (TNFRSF18) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF18 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF19	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 19 (TNFRSF19) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF19 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF1A	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF1A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF1B	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF1B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF21	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor receptor superfamily, member 21 (TNFRSF21) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF21 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF25	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 25 (TNFRSF25) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF25 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF4	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 4 (TNFRSF4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF6B	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF6B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF8	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 8 (TNFRSF8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFRSF9	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor receptor superfamily, member 9 (TNFRSF9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFRSF9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF10	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF11	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF11 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF12	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor superfamily member 12 (TNFSF12) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF12 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF13	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 13 (TNFSF13) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF13 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF13B	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF13B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF14	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor superfamily member 14 (TNFSF14) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF14 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF15	Human, Cynomolgus/Rhesus macaque, rat, mouse	Tumor necrosis factor superfamily member 15 (TNFSF15) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF15 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF18	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF18 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF4	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Tnfsf8	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 8 (Tnfsf8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-Tnfsf8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TNFSF9	Human, Cynomolgus/Rhesus macaque, rat, mouse	tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TNFSF9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

TNF Superfamily Regulators

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
TRAF6	Human, Cynomolgus/Rhesus macaque, rat, mouse	TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TRAF6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TRAF7	Human, Cynomolgus/Rhesus macaque, rat, mouse	TNF receptor-associated factor 7, E3 ubiquitin protein ligase (TRAF7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TRAF7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

VEGF Family

Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF). It is a signal protein produced by many cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis and angiogenesis. VEGF is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate such as in hypoxic conditions. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. It can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. GENEMEDI developed the c-fos induced growth factor (vascular endothelial growth factor D), fms-related tyrosine kinase 1, fms-related tyrosine kinase 4, Kinase insert domain receptor, placental growth factor, Vascular endothelial growth factor, Vascular endothelial growth factor A, Vascular endothelial growth factor B, Vascular endothelial growth factor C and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: VEGF Family Receptors VEGF Family Ligands

VEGF Family Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
VEGFB	Human, Cynomolgus/Rhesus macaque, rat, mouse	Vascular endothelial growth factor B (VEGFB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-VEGFB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
VEGFA	Human, Cynomolgus/Rhesus macaque, rat, mouse	Vascular endothelial growth factor A (VEGFA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-VEGFA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FIGF	Human, Cynomolgus/Rhesus macaque, rat, mouse	c-fos induced growth factor (vascular endothelial growth factor D) (FIGF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FIGF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PGF	Human, Cynomolgus/Rhesus macaque, rat, mouse	placental growth factor (PGF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PGF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

VEGF Family Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
KDR	Human, Cynomolgus/Rhesus macaque, rat, mouse	Kinase insert domain receptor (KDR) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-KDR monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FLT1	Human, Cynomolgus/Rhesus macaque, rat, mouse	fms-related tyrosine kinase 1 (FLT1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FLT1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
VEGFC	Human, Cynomolgus/Rhesus macaque, rat, mouse	Vascular endothelial growth factor C (VEGFC) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-VEGFC monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FLT4	Human, Cynomolgus/Rhesus macaque, rat, mouse	fms-related tyrosine kinase 4 (FLT4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FLT4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Chemokines and Chemokine Receptors

Chemokines are highly conserved cytokines that control the movement of cells around the body. Chemokines, or chemotactic cytokines, are a large family of small soluble proteins, and are distinguished and classified, based on the presence of conserved cysteine residues, as ‘CC’, ‘CXC’, ‘C’ or ‘CX3C’. The receptors, in turn, are classified based on the ligands they bind. Upon binding of the chemokine to a cognate chemokine receptor, the receptor undergoes a conformational change exposing the highly conserved DRYLAIV domain. The exposed motif binds to neighboring G-proteins, kick-starting a signal transduction cascade which will ultimately cause the cell to polarize and initiate migration. The chemokine superfamily includes a large number of ligands that bind to a smaller number of receptors. The importance of the chemokines has grown in recent years, as it has become recognized that they are key players in many disease processes, including inflammation, autoimmune disease, infectious diseases (such as HIV/AIDS), and more recently, cancer (in particular in regulating metastasis). Multiple chemokine ligands can bind to the same receptor; the perceived complexity and promiscuity of receptor binding has often made this field a challenge to understand and given the impression that chemokines lack specific effects. GENEMEDI developed the chemokines receptor and ligand such as atypical chemokine receptor 4, chemokine (C-C motif) receptor 1 to 10, chemokine (C-C motif) receptor-like 2, chemokine (C-X3-C motif) receptor 1, chemokine (C-X-C motif) receptor 1 to 7, family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 to A4, interleukin 8, platelet factor 4, X-C motif chemokine receptor 1, chemokine (C motif) ligand 1 to 28, chemokine (C-X3-C motif) ligand 1, chemokine (C-X-C motif) ligand 1, 2,3, 6, 7, 9 to 16 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Chemokines Receptors Chemokines Ligands

Chemokines Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
CCR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 1 (CCR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR10	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 10 (CCR10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR2	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 2 (CCR2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR3	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 3 (CCR3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR4	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 4 (CCR4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR5	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 5 (CCR5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR6	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 6 (CCR6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR7	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 7 (CCR7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR8	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 8 (CCR8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCR9	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor 9 (CCR9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCR9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCRL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	atypical chemokine receptor 4 (CCRL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCRL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCRL2	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) receptor-like 2 (CCRL2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCRL2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CX3CR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X3-C motif) receptor 1 (CX3CR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CX3CR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) receptor 1 (CXCR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCR2	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) receptor 2 (CXCR2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCR2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCR3	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) receptor 3 (CXCR3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCR3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCR4	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) receptor 4 (CXCR4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCR4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCR5	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) receptor 5 (CXCR5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCR5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCR6	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) receptor 6 (CXCR6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCR6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCR7	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) receptor 7 (CXCR7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCR7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
XCR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	X-C motif chemokine receptor 1 (XCR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-XCR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Chemokines Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
CCL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 1 (CCL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL11	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 11 (CCL11) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL11 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL13	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 13 (CCL13) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL13 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL14	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 14 (CCL14) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL14 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL15	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 15 (CCL15) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL15 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL16	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 16 (CCL16) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL16 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL17	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 17 (CCL17) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL17 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL18	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL18 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL19	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 19 (CCL19) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL19 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL20	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 20 (CCL20) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL20 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL21	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 21 (CCL21) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL21 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL22	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 22 (CCL22) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL22 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL23	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 23 (CCL23) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL23 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL24	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 24 (CCL24) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL24 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL25	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 25 (CCL25) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL25 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL26	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 26 (CCL26) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL26 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL27	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 27 (CCL27) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL27 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL28	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 28 (CCL28) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL28 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL3	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 3 (CCL3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL5	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 5 (CCL5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL7	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 7 (CCL7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CCL8	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 8 (CCL8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CX3CL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X3-C motif) ligand 1 (CX3CL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CX3CL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 1 (CXCL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL10	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 10 (CXCL10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL11	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 11 (CXCL11) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL11 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL12	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 12 (CXCL12) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL12 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL13	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 13 (CXCL13) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL13 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL14	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 14 (CXCL14) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL14 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL15	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 15 (CXCL15) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL15 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL16	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 16 (CXCL16) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL16 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL2	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 2 (CXCL2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL3	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 3 (CXCL3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL6	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 6 (CXCL6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CXCL9	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-X-C motif) ligand 9 (CXCL9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CXCL9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FAM19A2	Human, Cynomolgus/Rhesus macaque, rat, mouse	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 (FAM19A2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FAM19A2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FAM19A3	Human, Cynomolgus/Rhesus macaque, rat, mouse	family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 (FAM19A3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FAM19A3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FAM19A4	Human, Cynomolgus/Rhesus macaque, rat, mouse	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 (FAM19A4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FAM19A4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PF4	Human, Cynomolgus/Rhesus macaque, rat, mouse	platelet factor 4 (PF4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PF4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PPBP	Human, Cynomolgus/Rhesus macaque, rat, mouse	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (PPBP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PPBP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
XCL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C motif) ligand 1 (XCL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-XCL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-1 Family

IL-1 has served as a ground breaking molecule in immunology and it is now experiencing a renaissance.  The IL-1 family of ligands and receptors is primarily associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor family member contains the Toll-IL-1-receptor domain. This domain is also present in each Toll-like receptor, the receptors that respond to microbial products and viruses. Since Toll-IL-1-receptor domains are functional for both receptor families, responses to the IL-1 family are fundamental to innate immunity. The family of IL-1 and IL-1R have been identified and their function has been defined in innate and adaptive immune responses. IL-1 family members have emerged as key players in the differentiation of the main T helper subsets, Th1, Th2, and Th17. Anti-IL-1 strategies have had a tremendous impact in autoinflammatory diseases and are being tested in a variety of clinical conditions. GENEMEDI developed the IL-1 receptor and ligand such as IL-1 F6, IL-1 R6, IL-1 receptor accessory protein, IL-1 receptor accessory protein-like 1, IL-1 receptor antagonist, IL-1 receptor, type I and II, IL-1 receptor-like 1, IL-1 alpha, IL18, IL 18 binding protein, IL 18 receptor 1, IL 2 receptor, type IV, IL 33, IL 36 receptor antagonist, IL 36 beta, IL 36 gamma, IL 37, IL -1 Beta, IL -1 receptor, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, transmembrane emp24 protein transport domain containing 1 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-1 Receptors IL-1 Ligands IL-18 Binding Proteins

IL-1 Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
SIGIRR	Human, Cynomolgus/Rhesus macaque, rat, mouse	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SIGIRR monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1R1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 1 receptor, type I (IL1R1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1R1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1RL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 1 receptor-like 1 (IL1RL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1RL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1R2	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 1 receptor, type II (IL1R2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1R2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1RL2	Human, Cynomolgus/Rhesus macaque, rat, mouse	IL-1 R6 (IL1RL2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1RL2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1RAP	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 1 receptor accessory protein (IL1RAP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1RAP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TMED1	Human, Cynomolgus/Rhesus macaque, rat, mouse	transmembrane emp24 protein transport domain containing 1 (TMED1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TMED1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL18R1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 18 receptor 1 (IL18R1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL18R1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1RAPL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 1 receptor accessory protein-like 1 (IL1RAPL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1RAPL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-1 Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL18	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 18 (IL18) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL18 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Il1b	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin-1 Beta (Il1b) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-Il1b monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL1RN	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 1 receptor antagonist (IL1RN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL1RN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL33	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 33 (IL33) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL33 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL36A	Human, Cynomolgus/Rhesus macaque, rat, mouse	IL-1 F6 (IL36A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL36A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL36B	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 36, beta (IL36B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL36B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL36G	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 36, gamma (IL36G) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL36G monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL36RN	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 36 receptor antagonist (IL36RN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL36RN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL37	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 37 (IL37) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL37 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-18 Binding Proteins

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL18BP	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 18 binding protein (IL18BP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL18BP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-6 Family

Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I–III) based on structural features, receptor usage, cellular source and biological activities. The type I IFNs include the IFN-alpha family, IFN-beta, -omega, -kappa and Limitin/IFN-zeta and are important for regulating the immune response to viral infection. The type II IFN group includes only IFN-gamma. IFN-gamma is a multifunctional cytokine that exerts anti-proliferative, immunoregulatory, and pro-inflammatory effects important for numerous aspects of the immune response. The type III IFN family includes IL-29/IFN-lambda 1, IL-28A/IFN-lambda 2, IL-28B/IFN-lambda 3, and IFN-lambda 4. Similar to the type I IFNs, type III IFNs have anti-viral, anti-proliferative, and immunoregulatory effects. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with polymorphisms and mutations, can modulate the extent of IFN responses and the susceptibility to infections. Interactions between IFN types may occur, for both antiviral and cell-modulatory effects, in a complex interplay, involving both synergistic and antagonistic effects. Interferon-associated diseases, not related to virus infections may occur, some of them frequently observed in IFN-treated patients. On the whole, IFNs are pleiotropic biologic response modifiers, that, upon activation of thousands of genes, induce a broad spectrum of activities, regulating cell cycle, differentiation, plasma membrane molecules, release of mediators, etc., that can be relevant for cell proliferation, innate and adaptive immunity, hematopoiesis, angiogenesis and other body functions. GENEMEDI developed the interferon, alpha 2, interferon, interferon (alpha, beta and omega) receptor 2, interferon alpha, interferon gamma receptor 1, interferon gamma receptor 2 (interferon gamma transducer 1), interferon zeta, interferon alpha 1, 4, 5, 7, 8, 10,13,14, 16, 17 and 21, interferon beta 1 fibroblast, interferon epsilon, interferon gamma, interferon kappa, interferon lambda 1 and 3, interferon lambda receptor 1, interferon omega 1, interferon-alpha/beta receptor alpha chain-like interferon-gamma and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-6 Family Receptors IL-6 Family Ligands

IL-6 Family Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL11RA	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 11 receptor, alpha (IL11RA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL11RA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL31RA	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 31 receptor A (IL31RA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL31RA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CRLF1	Human, Cynomolgus/Rhesus macaque, rat, mouse	cytokine receptor-like factor 1 (CRLF1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CRLF1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL6R	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 6 receptor (IL6R) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL6R monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
LIFR	Human, Cynomolgus/Rhesus macaque, rat, mouse	leukemia inhibitory factor receptor (LIFR) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-LIFR monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
OSMR	Human, Cynomolgus/Rhesus macaque, rat, mouse	oncostatin M receptor (OSMR) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-OSMR monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CNTFR	Human, Cynomolgus/Rhesus macaque, rat, mouse	ciliary neurotrophic factor receptor (CNTFR) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CNTFR monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL6ST	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 6 signal transducer (IL6ST) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL6ST monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-6 Family Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
Il31	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 31 (Il31) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-Il31 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CLCF1	Human, Cynomolgus/Rhesus macaque, rat, mouse	cardiotrophin-like cytokine factor 1 (CLCF1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CLCF1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CTF1	Human, Cynomolgus/Rhesus macaque, rat, mouse	cardiotrophin 1 (CTF1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CTF1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL11	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 11 (IL11) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL11 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CNTF	Human, Cynomolgus/Rhesus macaque, rat, mouse	ciliary neurotrophic factor (CNTF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CNTF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
LIF	Human, Cynomolgus/Rhesus macaque, rat, mouse	leukemia inhibitory factor (LIF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-LIF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
OSM	Human, Cynomolgus/Rhesus macaque, rat, mouse	oncostatin M (OSM) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-OSM monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-10 Family

Interleukin-10 (IL-10) is a cytokine that elicits potent anti-inflammatory responses. IL-10 regulates the adaptive arm of the immune response by reducing the antigen presentation potential of innate cells by decreasing their surface major histocompatibility complex (MHC) levels and costimulatory molecules. In addition, IL-10 potently suppresses the production of proinflammatory cytokines from various cell types including monocytes, macrophages and T cells. The IL-10 receptor belongs to the class II cytokine receptor family, other members of which include the receptors for both type I and II interferons, tissue factor and the orphan receptors CRF2–8 and CRF2–9. Several recently discovered members of the cytokine receptor class II family have been shown to be structurally related to the IL-10 receptor. These include the receptors for IL-20 and IL-22. However, while signaling through these receptors seems to activate the same signal transduction components, they lead to different cellular responses, suggesting the presence of additional pathways and regulatory levels. IL-10 exerts its effects by binding to a surface receptor comprised of two IL-10Rα and two IL-10Rβ receptor subunits, which triggers the activation of the JAK1 (Janus kinase 1)/TYK2 (tyrosine kinase 2)/STAT3 (signal transducer and activator of transcription 3)/ STAT1 signalling pathway and the induction of specific gene expression programs. GENEMEDI developed the IL-10 and receptor such as IL-26, IL-10, IL-19, IL-24, IL-20, IL-22, IL-10 receptor beta and alpha, IL-20 receptor subunit alpha and beta, IL-22 receptor alpha 1, IL-22 receptor alpha 2 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-10 Family Ligands IFNs Receptors IL-10 Family Receptors

IL-10 Family Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL26	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 26 (IL26) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL26 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL24	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 24 (IL24) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL24 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL20	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 20 (IL20) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL20 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL22	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 22 (IL22) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL22 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL19	Human, Cynomolgus/Rhesus macaque, rat, mouse	IL19 (IL19) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL19 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IFNs Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL10RB	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 10 receptor, beta (IL10RB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL10RB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-10 Family Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL10RA	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 10 receptor, alpha (IL10RA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL10RA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL20RB	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 20 receptor subunit beta (IL20RB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL20RB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL22RA1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 22 receptor, alpha 1 (IL22RA1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL22RA1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL20RA	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 20 receptor subunit alpha (IL20RA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL20RA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL22RA2	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 22 receptor, alpha 2 (IL22RA2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL22RA2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-12 Family

Interleukin-12 (IL12) is a pro-inflammatory heterodimeric cytokine that stimulates the proliferation of activated T and NK cells, enhances their cytolytic activity, and induces inflammatory process via IFN-γ production. IL12 cytokine produced by myeloid cells, mediate innate and adaptive immunity. It consists of two disulfide-linked subunits, p35 and p40 that act as ligand and binds with the interleukin-12 receptor (IL12R). IL12R is a member of the hematopoietin receptor family that activates the signals via a conserved JAK-STAT intracellular pathway. The receptor consists of two chains IL-12Rβ1 and IL-12Rβ2. IL-12Rβ1 subunit associates with IL-12Rβ2 subunit and forms the receptor complex. The receptor complex binds with IL12 ligand and activates the downstream IL-12 signaling pathway of signal transduction. The interaction of IL12 ligand and IL12R has shown to play a critical role in innate and adaptive immunity and significantly affect immunodeficiency and several infectious diseases. GENEMEDI developed the IL-12 and receptor such as IL12, IL-12 p70, IL-12 receptor, beta 1 and beta 2, IL-12b, IL-23 receptor, IL-23, alpha subunit p19, IL-27, IL-27 receptor, alpha, marmoset interleukin IL-23 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-12 Family Ligands IL-12 Family Receptors

IL-12 Family Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL12	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 12 (IL12) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL12 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL12A	Human, Cynomolgus/Rhesus macaque, rat, mouse	IL-12 p70 (IL12A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL12A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL12B	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 12b (IL12B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL12B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL23	Human, Cynomolgus/Rhesus macaque, rat, mouse	Marmoset interleukin IL-23 (IL23) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL23 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL23A	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 23, alpha subunit p19 (IL23A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL23A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL27	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 27 (IL27) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL27 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-12 Family Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL12RB1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 12 receptor, beta 1 (IL12RB1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL12RB1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL12RB2	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 12 receptor, beta 2 (IL12RB2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL12RB2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL23R	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 23 receptor (IL23R) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL23R monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL27RA	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 27 receptor, alpha (IL27RA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL27RA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-17 Family

IL-17 family of cytokines are known to have pro-inflammatory actions and play a biological role by forming homodimers to bind to specific receptors which allows for signaling. Produced exclusively by Th17 cells and by a variety of innate immune cells, IL-17 members allow for the recruitment of neutrophils and promote a variety of cells to release inflammatory factors, adhesion molecules and growth and cell proliferation factors which contribute to the development of inflammation, immune response, immune rejection and other biologically active processes. IL-17 family consists of six members in mammals, i.e., IL-17A–F. Both IL-17A and IL-17F can stimulate the production of IL-6, IL-8, and granulocyte colony-stimulating factor (G-CSF), making IL-17 family bona fide pro-inflammatory cytokines. The IL-17 receptor family consists of 5 members, IL-17 receptor A (IL-17RA or IL-17R), IL-17 receptor B (IL-17RB or IL-17BR), IL-17 receptor C (IL17RC), IL-17 receptor D (IL-17RD), and IL-17 receptor E (IL17RE). IL-17 family mainly activate nuclear factor-kappaB (NF-κB) pathway through NF-κB activator 1 (Act1) and TNF (tumor necrosis factor) receptor associated factor 6 (TRAF6), and play important roles in promoting autoimmune diseases including rheumatoid arthritis, psoriasis and multiple sclerosis, and in controlling certain bacterial and fungal infections. GENEMEDI developed the interleukin 17, interleukin 17 receptor A, B, C, D and E, interleukin 17B to 17F, interleukin 25, marmoset interleukin IL17 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IL-17 Family Receptors IL-17 Family Ligands

IL-17 Family Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL17RA	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 17 receptor A (IL17RA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17RA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17RB	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 17 receptor B (IL17RB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17RB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17RC	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 17 receptor C (IL17RC) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17RC monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17RD	Human, Cynomolgus/Rhesus macaque, rat, mouse	IL17RD interleukin 17 receptor D (IL17RD) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17RD monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17RE	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 17 receptor E (IL17RE) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17RE monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IL-17 Family Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IL17	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 17 (IL17) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17A	Human, Cynomolgus/Rhesus macaque, rat, mouse	Marmoset interleukin IL17 (IL17A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17B	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 17B (IL17B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17C	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 17C (IL17C) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17C monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17D	Human, Cynomolgus/Rhesus macaque, rat, mouse	interleukin 17D (IL17D) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17D monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL17F	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 17F (IL17F) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL17F monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IL25	Human, Cynomolgus/Rhesus macaque, rat, mouse	Interleukin 25 (IL25) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IL25 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Activins Family

Activin has been established as a multifunctional regulatory protein with a broad spectrum of biological effects in developing as well as in mature tissues and organ systems. Activin has been shown to play a major role in proliferation, differentiation, apoptosis, inflammation, immunoregulation, tissue homeostasis and repair. Activin signals are transmitted through two types of transmembrane serine/threonine kinase receptors, type I and type II activin receptors in target cells. Activin receptors are prototypes of single-pass transmembrane serine/threonine kinases. Intriguingly, activin receptors are shared by other TGF-β family proteins, such as myostatin, growth and differentiation factor 11 (GDF11) and nodal. Therefore, several activities of these ligands are redundant with those of activins. GENEMEDI developed the activin modulators, receptor and ligand such as Activin, activin A receptor, type I, IA, IB, IC, IIA, IIB, Follistatin, follistatin-like 1, follistatin-like 3 (secreted glycoprotein), follistatin-like 4, follistatin-like 5, Activin type II receptor, activin A receptor type II-like 1, follistatin-like 4 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Activins Receptor Activins Modulators

Activins Receptor

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
ACVR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	activin A receptor, type I (ACVR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ACVR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ACVR1B	Human, Cynomolgus/Rhesus macaque, rat, mouse	activin A receptor, type IB (ACVR1B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ACVR1B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ACVR1C	Human, Cynomolgus/Rhesus macaque, rat, mouse	activin A receptor, type IC (ACVR1C) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ACVR1C monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ACVR2A	Human, Cynomolgus/Rhesus macaque, rat, mouse	activin A receptor, type IIA (ACVR2A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ACVR2A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ACVR2B	Human, Cynomolgus/Rhesus macaque, rat, mouse	activin A receptor, type IIB (ACVR2B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ACVR2B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ACVRL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	activin A receptor type II-like 1 (ACVRL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ACVRL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Activins Modulators

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
FST	Human, Cynomolgus/Rhesus macaque, rat, mouse	follistatin (FST) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FST monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FSTL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	follistatin-like 1 (FSTL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FSTL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FSTL3	Human, Cynomolgus/Rhesus macaque, rat, mouse	follistatin-like 3 (secreted glycoprotein) (FSTL3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FSTL3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FSTL4	Human, Cynomolgus/Rhesus macaque, rat, mouse	follistatin-like 4 (FSTL4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FSTL4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FSTL5	Human, Cynomolgus/Rhesus macaque, rat, mouse	follistatin-like 5 (FSTL5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FSTL5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

SMAD Family

Smads are a family of intracellular proteins that mediate signaling by members of the TGF-beta superfamily. Smads are divided into three distinct subgroups based on their different roles in TGF-beta family signal transduction: R-Smads (receptor-regulated), Co-Smads (common partner), and I-Smads (inhibitory). In general, activation of TGF-beta superfamily serine/threonine kinase receptors leads to the phosphorylation of R-Smads (Smads1, 2, 3, 5, and 8). This is followed by recruitment of the Co-Smad (Smad-4) into an R-Smad/Co-Smad complex that translocates to the nucleus to regulate gene expression. I-Smads (Smad6 and Smad7) antagonize this signaling pathway by preventing R-Smads from interacting with the receptor, or by competing with Co-Smads for the generation of R-Smad/Co-Smad complexes. Ligand-induced activation of TGF-β family receptors with intrinsic serine/threonine kinase activity trigger phosphorylation of receptor-regulated Smads (R-Smads). Activated R-Smads form heteromeric complexes with common-partner Smads (Co-Smads), e.g. Smad4, which translocate efficiently to the nucleus, where they regulate, in co-operation with other transcription factors, coactivators and corepressors, the transcription of target genes. Inhibitory Smads act in most cases in an opposite manner from R- and Co-Smads. Like other components in the TGF-β family signaling cascade, Smad activity is intricately regulated. The multifunctional and context dependency of TGF-β family responses are reflected in the function of Smads as signal integrators. Certain Smads are somatically mutated at high frequency in particular types of human cancers. Gene ablation of Smads in the mouse has revealed their critical roles during embryonic development. GENEMEDI developed the linker-phosphorylated Smad3, SMAD family member 2, SMAD family member 4, SMAD family member 9 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: SMAD Ligands

SMAD Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
SMAD1	Human, Cynomolgus/Rhesus macaque, rat, mouse	SMAD family member 1 (SMAD1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SMAD1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SMAD2	Human, Cynomolgus/Rhesus macaque, rat, mouse	SMAD family member 2 (SMAD2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SMAD2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SMAD3	Human, Cynomolgus/Rhesus macaque, rat, mouse	SMAD family member 3 (SMAD3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SMAD3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SMAD7	Human, Cynomolgus/Rhesus macaque, rat, mouse	SMAD family member 7 (SMAD7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SMAD7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SMAD9	Human, Cynomolgus/Rhesus macaque, rat, mouse	SMAD family member 9 (SMAD9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SMAD9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Bone morphogenetic proteins family

Bone morphogenetic proteins (BMPs) are secreted cytokines, which exhibit broad spectra of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-β (TGF-β) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signaling pathways. Recent findings have revealed that BMP signaling is finely tuned by various mechanisms in both positive and negative fashions. Perturbations of BMP signaling pathways are linked to a wide variety of clinical disorders, including vascular diseases, skeletal diseases and cancer. Administration of recombinant BMP ligands and increasing endogenous expression of BMPs provide therapeutic effects on some diseases. The recent development of BMP receptor inhibitors may also prove useful for some clinical diseases induced by hyperactivation of the BMP signaling pathways. GENEMEDI developed the BMP such as amphiregulin, betacellulin, BMP 1, 2, 2a, 2b, 3, 4, 6, 7, 8a, 8b, BMP receptor type IA, type IB, type II (serine/threonine kinase), and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: BMP Ligands BMP Receptor

BMP Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
BMP1	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 1 (BMP1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP2	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 2 (BMP2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP2A	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 2a (BMP2A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP2A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
bmp2b	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 2b (bmp2b) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-bmp2b monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP3	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 3 (BMP3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP4	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 4 (BMP4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP5	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 5 (BMP5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP6	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 6 (BMP6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP7	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 7 (BMP7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP8A	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 8a (BMP8A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP8A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMP8B	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein 8b (BMP8B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMP8B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

BMP Receptor

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
BMPR1A	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein receptor, type IA (BMPR1A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMPR1A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMPR1B	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein receptor, type IB (BMPR1B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMPR1B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BMPR2	Human, Cynomolgus/Rhesus macaque, rat, mouse	bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BMPR2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IGF Family

The insulin-like growth factors (IGF-I and IGF-II) share sequence and structural similarities with insulin. IGFs have four domains in the order B, C, A, and D from the N terminus and three alpha helices making up the core structure. Insulin is produced as a propeptide which, when processed to the mature form, only has the B and A domains on separate chains linked as a dimer by disulphide bonds and having a similar helical structure to the IGFs. In contrast to the critical role of insulin in metabolic control, the IGFs act via the type 1 IGF receptor (IGF-1R) to promote cell proliferation, survival and differentiation. IGFs are essential for normal growth and development, and perturbation of IGF-I expression is associated with acromegaly (increased) or short stature (decreased). Disruption of IGF-II imprinting during development is associated with overgrowth in Beckwith-Wiedemann syndrome, whereas reduced paternal allele expression results in growth retardation in Silver-Russell syndrome. Furthermore, IGFs acting via the IGF-1R play a major role in promoting cancer cell growth and survival. GENEMEDI developed the insulin-like growth factors receptor and ligand such as cartilage intermediate layer protein nucleotide pyrophosphohydrolase, connective tissue growth factor, cysteine-rich, angiogenic inducer, 61, endothelial cell-specific molecule 1, IGF-like family member 1 and 2, IGF-like family receptor 1, insulin-like growth factor 1 and 2, insulin-like growth factor 2 mRNA binding protein 2, insulin-like growth factor 2 receptor, insulin-like growth factor binding protein 1 to 7, insulin-like growth factor binding protein, acid labile subunit, insulin-like growth factor binding protein-like 1, Insulin-like Growth Factor-I, Kazal-type serine peptidase inhibitor domain 1, nephroblastoma overexpressed, WNT1 inducible signaling pathway protein 1 and 3, and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IGF Binding Proteins / IGFBPs IGF Receptors IGF Ligands IGF Modulators

IGF Binding Proteins / IGFBPs

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IGFBP1	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein 1 (IGFBP1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBP1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFBP2	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein 2, 36kDa (IGFBP2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBP2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFBP3	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein 3 (IGFBP3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBP3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFBP4	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein 4 (IGFBP4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBP4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFBP5	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein 5 (IGFBP5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBP5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFBP6	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein 6 (IGFBP6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBP6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFBP7	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein 7 (IGFBP7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBP7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFBPL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein-like 1 (IGFBPL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFBPL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
KAZALD1	Human, Cynomolgus/Rhesus macaque, rat, mouse	Kazal-type serine peptidase inhibitor domain 1 (KAZALD1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-KAZALD1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IGF Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IGF2R	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor 2 receptor (IGF2R) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGF2R monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFLR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	IGF-like family receptor 1 (IGFLR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFLR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IGF Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IGFL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	IGF-like family member 1 (IGFL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFL2	Human, Cynomolgus/Rhesus macaque, rat, mouse	IGF-like family member 2 (IGFL2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFL2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGF1	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor 1 (IGF1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGF1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGF2	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor 2 (IGF2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGF2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IGF Modulators

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
CILP	Human, Cynomolgus/Rhesus macaque, rat, mouse	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CILP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WISP3	Human, Cynomolgus/Rhesus macaque, rat, mouse	WNT1 inducible signaling pathway protein 3 (WISP3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WISP3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NOV	Human, Cynomolgus/Rhesus macaque, rat, mouse	nephroblastoma overexpressed (NOV) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NOV monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CTGF	Human, Cynomolgus/Rhesus macaque, rat, mouse	connective tissue growth factor (CTGF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CTGF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ESM1	Human, Cynomolgus/Rhesus macaque, rat, mouse	endothelial cell-specific molecule 1 (ESM1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ESM1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WISP1	Human, Cynomolgus/Rhesus macaque, rat, mouse	WNT1 inducible signaling pathway protein 1 (WISP1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WISP1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IGFALS	Human, Cynomolgus/Rhesus macaque, rat, mouse	insulin-like growth factor binding protein, acid labile subunit (IGFALS) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IGFALS monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CYR61	Human, Cynomolgus/Rhesus macaque, rat, mouse	cysteine-rich, angiogenic inducer, 61 (CYR61) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CYR61 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Fibroblast growth factors family

Fibroblast growth factors (FGFs) comprise a structurally related family of 22 molecules. FGFs can be grouped into seven subfamilies based on their sequence similarities and functional properties. FGFs bind four high affinity, ligand-dependent FGF receptor tyrosine kinase molecules (FGFR1–4). In the presence of heparan sulfate (HS) glycosaminoglycans, FGFs stably bind FGFRs and lead to the formation of 2:2:2 FGF-FGFR-HS dimers, which enables the cytoplasmic kinase domains to transphosphorylate one another and become activated. FGFR activation results in the stimulation of various signal transduction cascades that have been implicated in multiple aspects of vertebrate and invertebrate embryonic development, tumor growth, angiogenesis, wound healing, and physiology. GENEMEDI developed the FGFs receptor and ligand such as alpha-2-macroglobulin, alpha-2-macroglobulin-like 1, canopy 2 homolog (zebrafish), fibroblast growth factor 1 to 23, fibroblast growth factor binding protein 1 to 3, fibroblast growth factor receptor 1 to 4 and 1a, fibroblast growth factor receptor substrate 2, fibroblast growth factor receptor-like 1, golgi glycoprotein 1, klotho, klotho beta, leucine-rich repeat, immunoglobulin-like and transmembrane domains 3, PTX3, shisa family member 4, sprouty homolog 1 to 3 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: FGF Ligands FGF Regulators FGF Receptor

FGF Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
FGF1	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 1 (acidic) (FGF1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF2	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 2 (basic) (FGF2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF3	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 3 (FGF3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF4	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 4 (FGF4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF5	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 5 (FGF5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF6	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 6 (FGF6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF7	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 7 (FGF7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF8	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 8 (FGF8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF9	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 9 (glia-activating factor) (FGF9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF10	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 10 (FGF10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF14	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 14 (FGF14) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF14 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF16	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 16 (FGF16) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF16 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF17	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 17 (FGF17) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF17 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF18	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 18 (FGF18) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF18 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF19	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 19 (FGF19) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF19 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF20	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 20 (FGF20) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF20 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF22	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 22 (FGF22) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF22 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGF23	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor 23 (FGF23) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGF23 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

FGF Regulators

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
SPRY3	Human, Cynomolgus/Rhesus macaque, rat, mouse	sprouty homolog 3 (Drosophila) (SPRY3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SPRY3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CNPY2	Human, Cynomolgus/Rhesus macaque, rat, mouse	canopy 2 homolog (zebrafish) (CNPY2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CNPY2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGFBP3	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor binding protein 3 (FGFBP3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFBP3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SHISA4	Human, Cynomolgus/Rhesus macaque, rat, mouse	shisa family member 4 (SHISA4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SHISA4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SPRY1	Human, Cynomolgus/Rhesus macaque, rat, mouse	sprouty homolog 1, antagonist of FGF signaling (Drosophila) (SPRY1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SPRY1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
A2ML1	Human, Cynomolgus/Rhesus macaque, rat, mouse	alpha-2-macroglobulin-like 1 (A2ML1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-A2ML1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FRS2	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor receptor substrate 2 (FRS2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FRS2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
LRIT3	Human, Cynomolgus/Rhesus macaque, rat, mouse	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 (LRIT3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-LRIT3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
KL	Human, Cynomolgus/Rhesus macaque, rat, mouse	klotho (KL) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-KL monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
SPRY2	Human, Cynomolgus/Rhesus macaque, rat, mouse	sprouty homolog 2 (Drosophila) (SPRY2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-SPRY2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
A2M	Human, Cynomolgus/Rhesus macaque, rat, mouse	alpha-2-macroglobulin (A2M) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-A2M monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGFBP2	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor binding protein 2 (FGFBP2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFBP2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGFBP1	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor binding protein 1 (FGFBP1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFBP1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PTX3	Human, Cynomolgus/Rhesus macaque, rat, mouse	PTX3 (PTX3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PTX3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
KLB	Human, Cynomolgus/Rhesus macaque, rat, mouse	klotho beta (KLB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-KLB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

FGF Receptor

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
FGFR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	Fibroblast growth factor receptor 1 (FGFR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGFR2	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor receptor 2 (FGFR2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFR2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGFR3	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor receptor 3 (FGFR3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFR3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGFR4	Human, Cynomolgus/Rhesus macaque, rat, mouse	Fibroblast growth factor receptor 4 (FGFR4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFR4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FGFRL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	fibroblast growth factor receptor-like 1 (FGFRL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FGFRL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GLG1	Human, Cynomolgus/Rhesus macaque, rat, mouse	golgi glycoprotein 1 (GLG1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GLG1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Wnt Family

Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds to receptors belonging to the Frizzled family or the ROR1/ROR2 and RYK family. This interaction governs the downstream signaling cascade (canonical/non-canonical), ultimately extending its effect on the cellular cytoskeleton, transcriptional control of proliferation and differentiation, and organelle dynamics. Anomalous Wnt signaling has been associated with several cancers, the most prominent ones being colorectal, breast, lung, oral, cervical, and hematopoietic malignancies. It extends its effect on tumorigenesis by modulating the tumor microenvironment via fine crosstalk between transformed cells and infiltrating immune cells, such as leukocytes. GENEMEDI developed the frizzled class receptor 1 to 10, wingless-related MMTV integration site 3, wingless-type MMTV integration site family member 1, 2, 2B, 3A, 4, 5A, 5B, 6,7A, 7B, 8A, 8B, 9A, 9B, 10A, 10B, 11, 16 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Frizzled Receptors Wnt Family Ligands

Frizzled Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
FZD1	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 1 (FZD1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD2	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 2 (FZD2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD3	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 3 (FZD3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD4	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 4 (FZD4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD5	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 5 (FZD5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD6	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 6 (FZD6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD7	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 7 (FZD7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD8	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 8 (FZD8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD9	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 9 (FZD9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
FZD10	Human, Cynomolgus/Rhesus macaque, rat, mouse	frizzled class receptor 10 (FZD10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-FZD10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Wnt Family Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
WNT1	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 1 (WNT1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT2	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family member 2 (WNT2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT2B	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 2B (WNT2B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT2B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT3	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-related MMTV integration site 3 (WNT3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT3A	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 3A (WNT3A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT3A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT4	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 4 (WNT4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT5A	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 5A (WNT5A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT5A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT5B	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 5B (WNT5B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT5B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT6	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 6 (WNT6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT7A	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 7A (WNT7A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT7A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT7B	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 7B (WNT7B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT7B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT8A	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 8A (WNT8A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT8A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT8B	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 8B (WNT8B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT8B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT9A	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 9A (WNT9A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT9A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT9B	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 9B (WNT9B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT9B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT10A	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 10A (WNT10A) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT10A monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT10B	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 10B (WNT10B) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT10B monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT11	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 11 (WNT11) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT11 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
WNT16	Human, Cynomolgus/Rhesus macaque, rat, mouse	wingless-type MMTV integration site family, member 16 (WNT16) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-WNT16 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

GDF Family

Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems. GENEMEDI developed the Growth differentiation factors such as growth differentiation factor 1 to 3, 5 to 7, 9 to 11, 15 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: GDF Ligands

GDF Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
GDF1	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 1 (GDF1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF2	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 2 (GDF2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF3	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 3 (GDF3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF5	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 5 (GDF5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF6	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 6 (GDF6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF7	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 7 (GDF7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF9	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 9 (GDF9) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF9 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF10	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 10 (GDF10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF11	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 11 (GDF11) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF11 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDF15	Human, Cynomolgus/Rhesus macaque, rat, mouse	growth differentiation factor 15 (GDF15) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDF15 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Epidermal growth factor family

Epidermal growth factor (EGF), is a growth factor that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. This stimulates ligand-induced dimerization,[13] activating the intrinsic protein-tyrosine kinase activity of the receptor (see the second diagram). The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell – a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR – that ultimately lead to DNA synthesis and cell proliferation. GENEMEDI developed the Epidermal growth factor receptor and ligand such as EGF-like-domain multiple 6, 7, 8, epidermal growth factor, epidermal growth factor receptor, epiregulin, epithelial mitogen, erbb2 interacting protein, erb-b2 receptor tyrosine kinase 2, 3, 4, heparin-binding EGF-like growth factor, leucine-rich repeats and immunoglobulin-like domains 3, neuregulin 1, 2, 3, 4, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1, SH3-domain kinase binding protein 1, STAM binding protein, transforming growth factor, alpha, Transmembrane protein with EGF-like and two follistatin-like domains1, and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: EGF Receptor EGF Ligands EGF Regulators

EGF Receptor

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
ERBB4	Human, Cynomolgus/Rhesus macaque, rat, mouse	erb-b2 receptor tyrosine kinase 4 (ERBB4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ERBB4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
EGFR	Human, Cynomolgus/Rhesus macaque, rat, mouse	epidermal growth factor receptor (EGFR) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EGFR monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

EGF Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
EGFL8	Human, Cynomolgus/Rhesus macaque, rat, mouse	EGF-like-domain, multiple 8 (EGFL8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EGFL8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TMEFF2	Human, Cynomolgus/Rhesus macaque, rat, mouse	Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TMEFF2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NRG1	Human, Cynomolgus/Rhesus macaque, rat, mouse	neuregulin 1 (NRG1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NRG1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TMEFF1	Human, Cynomolgus/Rhesus macaque, rat, mouse	transmembrane protein with EGF-like and two follistatin-like domains 1 (TMEFF1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TMEFF1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NRG3	Human, Cynomolgus/Rhesus macaque, rat, mouse	neuregulin 3 (NRG3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NRG3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ERBB3	Human, Cynomolgus/Rhesus macaque, rat, mouse	erb-b2 receptor tyrosine kinase 3 (ERBB3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ERBB3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
EGFL7	Human, Cynomolgus/Rhesus macaque, rat, mouse	EGF-like-domain, multiple 7 (EGFL7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EGFL7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
BTC	Human, Cynomolgus/Rhesus macaque, rat, mouse	betacellulin (BTC) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-BTC monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
EGF	Human, Cynomolgus/Rhesus macaque, rat, mouse	epidermal growth factor (EGF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EGF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NRG2	Human, Cynomolgus/Rhesus macaque, rat, mouse	neuregulin 2 (NRG2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NRG2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TGFA	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, alpha (TGFA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
EREG	Human, Cynomolgus/Rhesus macaque, rat, mouse	epiregulin (EREG) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EREG monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
LRIG3	Human, Cynomolgus/Rhesus macaque, rat, mouse	leucine-rich repeats and immunoglobulin-like domains 3 (LRIG3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-LRIG3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NRG4	Human, Cynomolgus/Rhesus macaque, rat, mouse	neuregulin 4 (NRG4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NRG4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
LRIG2	Human, Cynomolgus/Rhesus macaque, rat, mouse	leucine-rich repeats and immunoglobulin-like domains 2 (LRIG2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-LRIG2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
AREG	Human, Cynomolgus/Rhesus macaque, rat, mouse	amphiregulin (AREG) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-AREG monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
EGFL6	Human, Cynomolgus/Rhesus macaque, rat, mouse	EGF-like-domain, multiple 6 (EGFL6) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EGFL6 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
EPGN	Human, Cynomolgus/Rhesus macaque, rat, mouse	epithelial mitogen (EPGN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-EPGN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ERBB2	Human, Cynomolgus/Rhesus macaque, rat, mouse	erb-b2 receptor tyrosine kinase 2 (ERBB2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ERBB2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

EGF Regulators

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
STAMBP	Human, Cynomolgus/Rhesus macaque, rat, mouse	STAM binding protein (STAMBP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-STAMBP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
ERBB2IP	Human, Cynomolgus/Rhesus macaque, rat, mouse	erbb2 interacting protein (ERBB2IP) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ERBB2IP monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Interferons (IFNs) Family

Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I–III) based on structural features, receptor usage, cellular source and biological activities. The type I IFNs include the IFN-alpha family, IFN-beta, -omega, -kappa and Limitin/IFN-zeta and are important for regulating the immune response to viral infection. The type II IFN group includes only IFN-gamma. IFN-gamma is a multifunctional cytokine that exerts anti-proliferative, immunoregulatory, and pro-inflammatory effects important for numerous aspects of the immune response. The type III IFN family includes IL-29/IFN-lambda 1, IL-28A/IFN-lambda 2, IL-28B/IFN-lambda 3, and IFN-lambda 4. Similar to the type I IFNs, type III IFNs have anti-viral, anti-proliferative, and immunoregulatory effects. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with polymorphisms and mutations, can modulate the extent of IFN responses and the susceptibility to infections. Interactions between IFN types may occur, for both antiviral and cell-modulatory effects, in a complex interplay, involving both synergistic and antagonistic effects. Interferon-associated diseases, not related to virus infections may occur, some of them frequently observed in IFN-treated patients. On the whole, IFNs are pleiotropic biologic response modifiers, that, upon activation of thousands of genes, induce a broad spectrum of activities, regulating cell cycle, differentiation, plasma membrane molecules, release of mediators, etc., that can be relevant for cell proliferation, innate and adaptive immunity, hematopoiesis, angiogenesis and other body functions. GENEMEDI developed the interferon, alpha 2, interferon, interferon (alpha, beta and omega) receptor 2, interferon alpha, interferon gamma receptor 1, interferon gamma receptor 2 (interferon gamma transducer 1), interferon zeta, interferon alpha 1, 4, 5, 7, 8, 10,13,14, 16, 17 and 21, interferon beta 1 fibroblast, interferon epsilon, interferon gamma, interferon kappa, interferon lambda 1 and 3, interferon lambda receptor 1, interferon omega 1, interferon-alpha/beta receptor alpha chain-like interferon-gamma and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: IFNs Receptors IFNs Type I IFNs Type II IFNs Type III

IFNs Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IFNGR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon gamma receptor 1 (IFNGR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNGR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNGR2	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNGR2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNAR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon-alpha/beta receptor alpha chain-like (IFNAR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNAR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNAR2	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon (alpha, beta and omega) receptor 2 (IFNAR2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNAR2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNLR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, lambda receptor 1 (IFNLR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNLR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IFNs Type I

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IFNA1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 1 (IFNA1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA2	Human, Cynomolgus/Rhesus macaque, rat, mouse	IFNA2 interferon, alpha 2 (IFNA2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA4	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 4 (IFNA4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA5	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 5 (IFNA5) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA5 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA7	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 7 (IFNA7) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA7 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA8	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 8 (IFNA8) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA8 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA10	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 10 (IFNA10) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA10 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA13	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 13 (IFNA13) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA13 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA14	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 14 (IFNA14) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA14 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA16	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 16 (IFNA16) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA16 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA17	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 17 (IFNA17) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA17 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNA21	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, alpha 21 (IFNA21) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNA21 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNB1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, beta 1, fibroblast (IFNB1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNB1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNE	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, epsilon (IFNE) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNE monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNK	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, kappa (IFNK) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNK monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNW1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, omega 1 (IFNW1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNW1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IFNs Type II

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IFNG	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, gamma (IFNG) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNG monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

IFNs Type III

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
IFNL3	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, lambda 3 (IFNL3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNL3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
IFNL1	Human, Cynomolgus/Rhesus macaque, rat, mouse	interferon, lambda 1 (IFNL1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-IFNL1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Notch Family

Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. The Notch extracellular domain mediates interactions with DSL family ligands, allowing it to participate in juxtacrine signaling. The Notch intracellular domain acts as a transcriptional activator when in complex with CSL family transcription factors. Members of this Type 1 transmembrane protein family share several core structures, including an extracellular domain consisting of multiple epidermal growth factor (EGF)-like repeats and an intracellular domain transcriptional activation domain (TAD). Notch family members operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis, neurogenesis and homeostasis. The Notch signaling pathway is crucial for the majority of developmental programs and regulates multiple pathogenic processes. Notch family receptors’ activation has been largely related to its multiple effects in sustaining oncogenesis. The Notch signaling pathway constitutes an ancient and conserved mechanism for cell-to-cell communication. Notch signaling is heavily influenced by microenvironmental cues, including adjacent “sending cells” which present any of five Notch ligands to up to four Notch receptors expressed on so called “receiving cells”. Ligand bound and activated Notch receptors undergo a series of proteolytic cleavages which release an active intracellular domain (NICD). This transcriptionally active fragment translocates to the nucleus to act as a co-transcription factor. Common Notch signaling targets are transcription factors themselves, which have their own broader implications and cascades, culminating in a system that requires a fine-tuned, highly sensitive signaling network. Disruption of Notch signaling, both through over- and under-activation, leads to a variety of developmental abnormalities and cancers. Understanding mechanisms behind this precise level of internal control may pave the way for treatments of many of its resulting disorders. GENEMEDI developed the notch homolog 1, notch 2, notch 3, notch 4 and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: Notch Receptors

Notch Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
NOTCH1	Human, Cynomolgus/Rhesus macaque, rat, mouse	Notch homolog 1 (NOTCH1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NOTCH1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NOTCH2	Human, Cynomolgus/Rhesus macaque, rat, mouse	notch 2 (NOTCH2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NOTCH2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NOTCH3	Human, Cynomolgus/Rhesus macaque, rat, mouse	notch 3 (NOTCH3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NOTCH3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NOTCH4	Human, Cynomolgus/Rhesus macaque, rat, mouse	notch 4 (NOTCH4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NOTCH4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Platelet-derived growth factor family

Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. However, overactivity of PDGF signaling has been associated with the development of malignancies and other diseases involving excess cell proliferation. The PDGF family consists of PDGF-A, PDGF-B, PDGF-C and PDGF -D. The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The PDGF signalling network consists of five ligands, PDGF-AA through -DD (including -AB), and two receptors, PDGFR alpha and PDGFR beta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers. GENEMEDI developed the Platelet-derived growth factor (PDGF), platelet derived growth factor C, platelet derived growth factor D, platelet derived growth factor subunit B, platelet-derived growth factor alpha polypeptide, Platelet-derived growth factor receptor B, platelet-derived growth factor receptor-like, Platelet-derived growth factor receptors (PDGF-R) and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: PDGF Family Receptors PDGF Family Ligands

PDGF Family Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
PDGFRA	Human, Cynomolgus/Rhesus macaque, rat, mouse	Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of theplatelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiat (PDGFRA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PDGFRA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PDGFRL	Human, Cynomolgus/Rhesus macaque, rat, mouse	platelet-derived growth factor receptor-like (PDGFRL) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PDGFRL monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PDGFRB	Human, Cynomolgus/Rhesus macaque, rat, mouse	Platelet-derived growth factor receptor B (PDGFRB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PDGFRB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

PDGF Family Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
PDGFA	Human, Cynomolgus/Rhesus macaque, rat, mouse	platelet-derived growth factor alpha polypeptide (PDGFA) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PDGFA monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PDGFB	Human, Cynomolgus/Rhesus macaque, rat, mouse	platelet derived growth factor subunit B (PDGFB) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PDGFB monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PDGFC	Human, Cynomolgus/Rhesus macaque, rat, mouse	platelet derived growth factor C (PDGFC) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PDGFC monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PDGFD	Human, Cynomolgus/Rhesus macaque, rat, mouse	platelet derived growth factor D (PDGFD) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PDGFD monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

TGF-beta Family

The transforming growth factor beta (TGF-β) superfamily is a large family of growth factors named after the first member TGF-β1. TGF-β superfamily is involved in regulating and mediating processes at the cellular level, including cell proliferation, differentiation, motility, adhesion and apoptosis, as well as processes at the tissue and organism level, including development, wound healing, fibrosis and angiogenesis. The TGF-β superfamily consists of ligands and receptors that all signal, at least in part, through well characterized downstream mediators termed the Smads. The Transforming Growth Factor Beta (TGF-beta) superfamily consists of the TGF-beta proteins, Bone Morphogenetic Proteins (BMPs), Growth Differentiation Factors (GDFs), Glial-derived Neurotrophic Factors (GDNFs), Activins, Inhibins, Nodal, Lefty, and Mülllerian Inhibiting Substance (MIS). Ligands of the TGF-beta superfamily form dimers that bind to heterodimeric receptor complexes consisting of type I and type II receptor subunits with serine/threonine kinase domains. Following ligand binding, the type II receptor phosphorylates and activates the type I receptor, initiating a Smad-dependent signaling cascade that induces or represses transcriptional activity. Disruption of the TGF-β pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-β acts as a tumor suppressor; however, in tumor cells, TGF-β loses anti-proliferative response and become an oncogenic factor. GENEMEDI developed the CD109 molecule, transforming growth factor beta 1 induced transcript 1, transforming growth factor beta receptor III, transforming growth factor beta-induced 68kDa and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: TGF-β Receptors TGF-β Ligands

TGF-β Receptors

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
TGFBR1	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, beta receptor 1 (TGFBR1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFBR1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TGFBR2	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, beta receptor II (70/80kDa) (TGFBR2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFBR2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TGFBR3	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, beta receptor III (TGFBR3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFBR3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
CD109	Human, Cynomolgus/Rhesus macaque, rat, mouse	CD109 molecule (CD109) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CD109 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

TGF-β Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
TGFBI	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, beta-induced, 68kDa (TGFBI) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFBI monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TGFB3	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, beta 3 (TGFB3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFB3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TGFB2	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, beta 2 (TGFB2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFB2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TGFB1	Human, Cynomolgus/Rhesus macaque, rat, mouse	transforming growth factor, beta 1 (TGFB1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-TGFB1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

Glial cell line-derived neurotrophic factor family

Glial cell line-derived neurotrophic factor (GDNF) family members are known to play a role in the developing and adult parasympathetic and enteric nervous systems. GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin.  These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures.  GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors.  GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. GENEMEDI developed the GDNF such as Artemin, GDNF family receptor alpha 1 to 4, GDNF family receptor alpha like, glial cell derived neurotrophic factor, neurturin, persephin and so on for several application such as cell culture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Classification: GDNF Receptor GDNF Ligands

GDNF Receptor

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
GFRAL	Human, Cynomolgus/Rhesus macaque, rat, mouse	GDNF family receptor alpha like (GFRAL) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GFRAL monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GFRA1	Human, Cynomolgus/Rhesus macaque, rat, mouse	GDNF family receptor alpha 1 (GFRA1) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GFRA1 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GFRA2	Human, Cynomolgus/Rhesus macaque, rat, mouse	GDNF family receptor alpha 2 (GFRA2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GFRA2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GFRA3	Human, Cynomolgus/Rhesus macaque, rat, mouse	GDNF family receptor alpha 3 (GFRA3) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GFRA3 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GFRA4	Human, Cynomolgus/Rhesus macaque, rat, mouse	GDNF family receptor alpha 4 (GFRA4) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GFRA4 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).

GDNF Ligands

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Order
ARTN	Human, Cynomolgus/Rhesus macaque, rat, mouse	artemin (ARTN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-ARTN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
GDNF	Human, Cynomolgus/Rhesus macaque, rat, mouse	glial cell derived neurotrophic factor (GDNF) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-GDNF monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
PSPN	Human, Cynomolgus/Rhesus macaque, rat, mouse	persephin (PSPN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-PSPN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
NRTN	Human, Cynomolgus/Rhesus macaque, rat, mouse	neurturin (NRTN) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-NRTN monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).