The world is in midst of the COVID-19 pandemic.The SARS-CoV-2 lineage B.1.1.28 has been evolving in Brazil since February 2020. A new lineage, named P.1 (B.1.1.28.1), contains convergent mutations in the spike (S) protein, including several receptor binding domain (spike RBD) mutations E484K, K417T, and N501Y.
Spike Mutation in SARS-COV-2 (2019nCOV) Brazilian variant P.1 lineage (B.1.1.28.1) |
Spike-S1 Subunit N Terminal |
L18F | |
T20N | |||
P26S | |||
D138Y | |||
R190S | |||
Spike-S1-RBD | K417N | Important residues mutation | |
E484K | |||
N501Y | |||
Spike-S1 Subunit C Terminal | D614G | A popular mutation in different new SARS-CoV-2 lineage | |
H655Y | |||
Spike-S2 Subunit | T1027I | ||
V1176F |
GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) P.1 lineage (B.1.1.28.1, Brazilian variant)
Taking responsibility to help accelerate the COVID-19 vaccine and therapeutic antibody discovery and development, GeneMedi had developed the pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) P.1 lineage(B.1.1.28.1, Brazilian variant), which will meet the evaluation of the efficacy of COVID19 vaccines and therapeutic antibodies.
SARS-COV-2 (2019nCOV)-P.1 lineage(B.1.1.28.1, Brazilian variant) of Spike protein & ACE2 competition binding assay for efficacy evaluation of COVID-19 vaccines and therapeutic antibodiess
GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) - P.1 lineage(B.1.1.28.1, Brazilian variant)
GeneMedi designed a mammalian expression codon-optimized spike mutation/deletion variant vector for COVID-19 SARS-COV-2 (2019nCOV) P.1 lineage(B.1.1.28.1, Brazilian variant)