Diagnostic antibodies and antigens for metabolic diseases testing: 25-OH-(VD3+VD2), PINP, β-CTx, 25-OH-VD, 25-OH-VD-3, SAHH, CBL, CBS, LP-PLA2, RBP4

Metabolism is the process of making energy from the food. metabolic disease, any of the diseases or disorders that disrupt normal metabolism, the process of converting food to energy on a cellular level. Thousands of enzymes participating in numerous interdependent metabolic pathways carry out this process. Metabolic diseases affect the ability of the cell to perform critical biochemical reactions that involve the processing or transport of proteins (amino acids), carbohydrates (sugars and starches), or lipids (fatty acids). The consequences of metabolic disorder may be severe; intellectual disability, seizures, decreased muscle tone, organ failure, blindness, and deafness may occur, depending on which enzyme is dysfunctional. Biomarker such as -25 hydroxyvitamin D, procollagen type I N-terminal propeptide (PINP), β-isomerized C-terminal telopeptides, 25-hydroxy (OH) Vitamin, S-adenosylhomocysteine (AdoHcy) hydrolase, cystathionine-β-synthase enzyme, Phospholipase A2, Retinol binding protein 4 and so on are suitable for monitoring metabolic disease. Detecting the quantity of these marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.