Diagnostic antibodies and antigens for fertility testing: Anti-Mullerian hormone (AMH), Fetal fibronectin (fFN), acrosome protein (ACRV1)

The pregnancy contains multiple steps that must effectively happen at a precise time and in the precise place. For fertilization, oocytes and sperm cells must experience a series of differentiation and development process. Abnormalities on the placement of embryo in the woman’s uterus, decidualization, placentation and intrauterine embryonic development consequence the onset of pre-eclampsia, miscarriage and/or preterm birth. On the other hand, sperm cells of the man should undergo capacitation and acrosome exocytosis to fertilize oocytes appropriately. A little imbalance in this process may disturb the capability of sperm cells to fertilize the egg. Thus, the detection of biomarkers to monitor the pregnancy process, and complication in both female and male gametes is an opportunity for successful pregnancy. Recently, several biomarkers have been developed to improve diagnostic accuracy. Indeed, GENEMEDI offer the biomarkers such as Anti-Mullerian hormone (AMH), Fetal fibronectin (fFN), acrosome protein and so on to make a successful pregnancy. Detecting the quantity of these marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.