Diagnostic antibodies and antigens for Neuropathy testing: tau proteins (tau), Phospho-tau181 (p-tau181), Phospho-tau217 (p-tau217), neurofilament light chain (NFL)

Neuropathy refers to the injury or dysfunction of one or more nerves, which results in numbness, tingling, muscle weakness and discomfort in the nerves affected part. Neuropathies often arise from the hands and feet, sometimes other parts of the body also affected. Peripheral neuropathy refers the injury or dysfunction of the peripheral nerves.  Peripheral neuropathy might be acute or chronic, and sometimes it is reversible. Neuropathy induces a series of complications in the health and develop the symptoms of those issues. Biochemical markers are increasingly used for the early diagnosis of the neuropathy. In addition, such markers may provide additional information for understanding the pathology of disease. Several markers such as a tau protein (tau), Phospho-tau181 (p-tau181), Phospho-tau217 (p-tau217), neurofilament light chain (NFL) and so on have been identified to be associated with the neuropathy disorder. Detecting the quantity of these marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

Genemedi supplies antibodies and antigens for Neuropathy testing for a wide selection of choices (please see below).

Tau
p-tau181
p-tau217
NFL

 

tau proteins (Tau)

Cat No.	Antibody/Antigen Name	Expression platform	Isotypes	Bioactivity validation	Order
GMP-Tau-Ag; GMP-Tau-Ab	Antigen: Recombinant tau proteins (Tau, His Tag); Antibody: Anti-tau proteins (tau) mouse monoclonal antibody(mAb)	Antigen: E.coli; Antibody:  Hybridoma	Antigen: Recombinant Antigen; Antibody: Mouse IgG	Antigen: tau proteins (Tau) Antibody Binding; Antibody: Human tau proteins (tau) protein binding, ELISA validated as capture antibody and detection antibody. Pair in tau level test and Neuropathy evaluation.

 

Phospho-tau181 (p-tau181)

Cat No.	Antibody/Antigen Name	Expression platform	Isotypes	Bioactivity validation	Order
GMP-p-tau181-Ab	Anti-Phospho-tau181 (p-tau181) mouse monoclonal antibody(mAb)	Hybridoma	Mouse IgG	Human Phospho-tau181 (p-tau181) protein binding, ELISA validated as capture antibody and detection antibody. Pair in p-tau181 level test and Neuropathy evaluation.
GMP-p-tau181-antigen	Phospho-tau181 (p-tau181) antigen	Synthetic	NA	Phospho-tau181 (p-tau181) Antibody Binding, Immunogen in positive control, Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT

 

Phospho-tau217 (p-tau217)

Cat No.	Antibody/Antigen Name	Expression platform	Isotypes	Bioactivity validation	Order
GMP-p-tau217-Ab	Anti-Phospho-tau217 (p-tau217) mouse monoclonal antibody(mAb)	Hybridoma	Mouse IgG	Human Phospho-tau217 (p-tau217) protein binding, ELISA validated as capture antibody and detection antibody. Pair in p-tau217 level test and Neuropathy evaluation.
GMP-p-tau217-antigen	Phospho-tau217 (p-tau217) antigen	Synthetic	NA	Phospho-tau217 (p-tau217) Antibody Binding, Immunogen in positive control, Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT

 

neurofilament light chain (NFL)

Cat No.	Antibody/Antigen Name	Expression platform	Isotypes	Bioactivity validation	Order
GMP-NFL-Ag	Recombinant neurofilament light chain (NFL, His Tag)	E.coli	Recombinant Antigen	neurofilament light chain (NFL) Antibody Binding, Immunogen in Sandwich ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT

 

 

GeneMedi’s p-tau217/Tau and p-tau181/Tau antibody pairs show good performance in serological diagnosis of Alzheimer’s Disease (AD) blood test

 

 

Established biomarkers for Alzheimer’s disease, including beta-amyloid (Aβ) and tau. Compared with CSF-based measurements, blood-based biomarkers have the potential to be deployed widely due to the lower costs and less invasiveness. Decreased beta-amyloid 42/beta-amyloid 40(Aβ42/Aβ40) ratio and increased p-tau217 and p-tau181 were associated with subsequent Alzheimer’s disease diagnosis¹. Both p-tau217 and p-tau181 had an excellent diagnostic performance for differentiating patients with Alzheimer’s disease syndromes from other neurodegenerative disorders. Besides, P-tau217 was a stronger indicator than p-tau181².

GeneMedi’s p-tau217/Tau and p-tau181/Tau antibody pairs show good performance in diagnosis of Alzheimer’s Disease blood test. Recently, Eli Lilly’s P-tau217 Serological Test also showed high accuracy in diagnosis of Alzheimer’s Disease, which was published in JAMA.

Cat No.	Antibody/Antigen Name
GMP-p-tau217-Ab	Anti-Phospho-tau217 (p-tau217) mouse monoclonal antibody(mAb)
GMP-p-tau217-antigen	Phospho-tau217 (p-tau217) antigen (positive control)
GMP-p-tau181-Ab	Anti-Phospho-tau181 (p-tau181) mouse monoclonal antibody(mAb)
GMP-p-tau181-antigen	Phospho-tau181 (p-tau181) antigen (positive control)
GMP-Tau-Ab	Anti-tau proteins (tau) mouse monoclonal antibody(mAb)

 

Reference

 

[1] Adam M. Brickman. Plasma p-tau181, p-tau217, and other blood-based Alzheimer’s disease biomarkers in a multi-ethnic, community study. Alzheimer’s Dement. 2021;17:1353–1364.

[2] Elisabeth H Thijssen. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer’s disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Lancet Neurol 2021; 20: 739–52.